人参粉对长期喂养去卵巢大鼠内分泌功能影响初探  

The First Exploration about Endocrine Function Effect of the Ovariectimized Rats Feeding Panax Ginseng Powder for Long-term

作　　者：常伟勤[1] 宋昕恬[2] 孟令仪[2] 张晶莹[2] 冯琳琳[1] 许天敏[1] 张琨[1] CHAGN Wei-qin SONG Xin-tian MENG Ling-yi et al(The Second Hospital Atteched Jilin University. Changchun 130041 ,China)

机构地区：[1]吉林大学第二医院,吉林长春130041 [2]吉林省疾病预防控制中心,吉林长春130062

出　　处：《中国实验诊断学》2017年第4期698-701,共4页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省教育厅"十三五"科学技术研究项目资金资助项目(吉教科合字[2016]第488号);吉林省科技厅项目资助(20150204041YY)

摘　　要：目的研究长期给予去卵巢大鼠一定剂量人参粉对其内分泌功能相关指标的影响。方法分别以0.5、1、3.0g/kg BW d人参粉掺入基础饲料喂饲去卵巢大鼠90d,另设给予基础饲料的假手术组及去卵巢大鼠对照组;试验结束取血测定血清部分内分泌功能相关指标;测定相关脏器系数并进行组织病理检查。结果给予不同剂量人参粉的去卵巢大鼠肾上腺/体重比,子宫/体重比及血清E2、T3、T4与去卵巢大鼠对照组比较有所增加;体重及血清FSH、LH与去卵巢大鼠对照组比较有所减少,且差异均有显著性(P<0.05)并呈现一定的剂量反应关系。结论一定剂量人参粉长期喂养去卵巢大鼠能够对雌激素水平突然下降导致的一系列内分泌功能及相关脏器的变化有所调节,提示了人参有可能改善妇女绝经期一系列症状。Objective study the effect of long term feeding ginseng powder on ovariectimized rats about endocrine function related index.Methods Three groups of ovariectimized rats were given with the dose of 0.5、1、3.0g/kg BW d ginseng powder mixtured with foundation animal feed;one ovariectimized rats group and one sham operation group were given foundation animal feed only for 90 days.At the end of the test,measure some endocrine function related index of the serum and organic coefficient of empty stomach rats,exam the organic pathology.Results After given with the different dose of ginseng powder mixtured with foundation animal feed,ratio of adrenal weight/body weight、uterine weight/body weight and E2、T3、T4of serum can be slightly increased compared with that of ovariectimized rats＇ group;the body weight and FSH、LH of serum can be decreased compared with that of ovariectimized rats＇ group.The difference is apparent（P〈0.05）and there is dose-effect relationship between 3ginseng powder groups,there was also some changes in organic pathological examination.Conclusion Long term feeding with the certain dose ginseng powder can regulate the changes about endocrine function related index of ovariectimized rats caused by the sudden drop of estrogen after ovariectomy,and there was no bad influence on rats＇ serum and organic pathology.That indicates ginseng powder＇s potential role on improving perimenopausal syndrome of older women.

关 键 词：人参粉 去卵巢大鼠 长期喂养 内分泌 

分 类 号：R285.5[医药卫生—中药学]