纤溶酶原激活抑制物-1基因4G/5G多态性与儿童青少年血糖及其相关指标的关系  

Association of 4G/5G polymorphism in PAI-1 gene with blood glucose and related phenotypes in children and adolescents

作　　者：宋洁云[1] 张怡宁[1] 阳益德[1] 王烁[1] 马军[1] 王海俊[2] SONG Jie-yun ZHANG Yi-ning YANG Yi-de et al(Institute of Child and Adolescent Health of Peking University, Beijing 100191, China)

机构地区：[1]北京大学儿童青少年卫生研究所,100191 [2]北京大学公共卫生学院妇女与儿童青少年卫生学系

出　　处：《中国糖尿病杂志》2017年第4期294-297,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金(81573170)

摘　　要：目的探讨纤溶酶原激活抑制物-1(PAI-1)基因4G/5G多态性与儿童青少年血糖及其相关指标的关系。方法选取北京市3919名7~18岁儿童青少年进行身体测量和FPG水平检测,部分样本检测FIns水平。利用基质支持的激光释放/电离飞行时间质谱分析(MALDI-TDF MS)对PAI-1基因4G/5G多态性进行检测。采用多元线性回归和Logistic二元回归分析基因多态性与血糖及相关指标的关系。结果校正研究人群、年龄和性别后发现,与5G5G基因型比较,4G等位基因携带者FPG水平较高(β=0.064,SE=0.029,P=0.025)。4G/5G多态性与IFG有相关性(OR=1.640,95%CI:1.166~2.309,P=0.005)。校正BMI后该多态性与IFG的相关性没有变化(FPG:β=0.063,SE=0.029,P=0.029;IFG:OR=1.628,95%CI:1.155~2.293,P=0.005)。结论 PAI基因4G/5G多态性与儿童青少年血糖水平和IFG有相关性,其效应独立于BMI的作用。Objective To explore the relationship between 4G/5G polyrnorphism in PAI-1 （plasminogen activator inhibitor-1） gene with blood glucose and glucose-related phenotypes in children and adolescents. Methods Total 3,919 children and adolescents aged 7 - 18 years were recruited. Anthropometric measurements and fasting blood glucose （FPG） detection were performed. Fasting insulin levels in a subgroup were detected. The matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI-TOF MS） was used to genotype 4G/SG polymorphism. Linear and logistic regressions were used to analyze the relationship between 4G/SG polymorphism and glucose and related phenotypes. Results Compared with 5G5G genotype,4G allele （4GSG and 4G4G） carriers had higher FPG, after adjustment for age, sex and study population （β= 0. 064, SE= 0. 029, P = 0. 025）. 4G/SG polymorphism was associated with risk of impaired fasting glucose （IFG） （OR= 1. 640,95 % CI： 1. 166 2. 309,P=0. 005）. The above correlation remained unchanged after further adjustment for body mass index （BMI） （fasting g[ucose..fl=0, 063,SE=0. 029,P=0. 029; IFG：OR=1. 628,95%CI：1. 155-2. 293, P= 0. 005 ）. Conclusion 4G/SG polymorphism in PAI-1 gene is associated with FPG and IFG in children and adolescents with its effect independent of BMI.

关 键 词：纤溶酶原激活抑制物基因 血糖 儿童 

分 类 号：R725.8[医药卫生—儿科]