鸽子海马区位置细胞及其空间响应特性分析  

Response properties of place cells in the hippocampus of freely moving pigeons

作　　者：刘新玉[1] 万红[1,2] 陈雪美[1] 尚志刚[1,2] 师丽[1,2,3] 李珊[1] 陈艳[1] 聂洁洁 LIU XinYu WAN Hong CHEN XueMei SHANG ZhiGang SHI Li LI Shah CHEN Yan NIE JieJie(School of Electrical Engineering, Zhengzhou University, Zhengzhou 450001, China Henan Key Laboratory of Brain Science and Brain-Computer Interface Technology, Zhengzhou University, Zhengzhou 450001, China Department of Automation, Tsinghua University, Belting 100084, China)

机构地区：[1]郑州大学电气工程学院,郑州450001 [2]郑州大学河南省脑科学与脑机接口技术重点实验室,郑州450001 [3]清华大学自动化系,北京100084

出　　处：《中国科学：生命科学》2017年第3期292-304,共13页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:61673353;U1304602)资助

摘　　要：位置细胞被认为是构成空间认知地图的基本单元,对于动物空间认知具有十分重要的作用.为了解析鸟类的空间认知神经机制,本文以鸽子(Columba)为模式动物,设计了4种目标明确程度不同的空间认知任务,利用12只鸽子海马区记录的位置细胞,从定性、定量和稳定性3个方面对比了有目标和无目标环境中位置细胞的空间响应特性.结果表明,有目标环境比无目标环境更易诱发出位置野,且位置野的稳定性随环境中目标明确程度的提高而增加.此外,鸽子海马区位置细胞一般具有多个位置野,平均每个位置细胞有2.7个位置野,同时记录的位置细胞位置野基本处于相近的位置上,大部分都有重叠.本文的研究成果将有助于深化对不同物种动物空间认知机制的理解,也将为进一步解析鸽子的三维空间认知和导航机制奠定基础.Place cells are considered to be the basic unit of cognitive maps, which play an important role in spatial cognition for many animals. To investigate the neural mechanisms underlying spatial cognition in birds, we designed four spatial cognitive tasks with or without goals, using pigeons as an animal model. We examined place cells in the hippocampus of 12 pigeons while they performed each task. We measured their spatial response properties and comparatively analyzed place field properties between tasks with and without goals using qualitative and quantitative measures. The results revealed that the reliability of place fields increased when the presence of a goal was clearer, and that place fields were more easily activated in tasks with a goal compared with those with no goal. In addition, we found that place cells in the hippocampus generally possessed multiple place fields, with an average of 2.7 place fields for each place cell. Place fields recorded simultaneously were always located in a similar position, and most exhibited overlapping regions. These results will be helpful for extending our understanding of the mechanisms underlying spatial cognition in different species, and provide a foundation for future studies investigating three-dimensional spatial cognition and navigation mechanisms in pigeons.

关 键 词：鸽子 海马区 位置细胞 位置野 空间响应特性 稳定性 

分 类 号：Q42[生物学—神经生物学]