使用超高效液相色谱-串联飞行时间质谱(Q-Tof)和UNIFI筛查软件进行动物尿液中兽药及违禁药物筛查分析  

The screening analysis of veterinary and illegal drugs in urine by ultraperformance liquid chromatography tandem time of flight mass spectrometer (Q-Tof) system combines UNIFI screening software

作　　者：杨盛茹[1] 李颖[2] 蔡英华[2] 刘洪斌[2] 

机构地区：[1]河南牧业经济学院食品工程学院,郑州450046 [2]中国动物疫病预防控制中心,北京102609

出　　处：《分析试验室》2017年第4期418-422,共5页Chinese Journal of Analysis Laboratory

基　　金：十二五国家科技支撑计划项目(2014BAD13B05)资助

摘　　要：利用高分辨飞行时间质谱(Q-Tof)和UNIFI筛查软件对动物尿液中部分兽药及违禁药物进行筛查分析,并对筛查结果进行LC-MS/MS方法进行确证。4份动物尿液样品经MSE数据采集模式并经UNIFI软件筛查分析,分别检出2~7种残留物。以沙丁胺醇为例,筛查结果经LC-M S/M S确证,两种方法结果一致。筛查结果表明,UPLC-Q-Tof系统结合UNIFI筛查软件适用于动物源性产品中多种药物残留的同时筛查,筛查结果准确可靠。Veterinary and illegal drugs were screened and analyzed by mass spectrometer （Q-Tof） and UNIFI screening software. The screening high-resolution time of flight results was further identified by LC-MS/MS. The data of four animal urine samples was collected upon MSE mode and analyzed by UNIFI software, with two-seven residues detected respectively. Taking salbutamol as example, results detected by LC-MS/MS were consistent with screening results. The results show that it is suitable, accurate and reliable to combine UPLC-Q-T of system with UNIFI screening software for multi-residue determination with animal products.

关 键 词：飞行时间质谱 动物尿液 兽药 筛查分析 

分 类 号：R991[医药卫生—毒理学]