山楂降脂散对高脂血症患者血脂的影响：附484例患者的病例分析  

Effect of Hawthorn Jiangzhi powder on blood lipids in patients with hyperlipidemia： a pathological analysis of 484 cases

作　　者：杨铁骊[1] 张小方[1] 潘胜军[1] 张小照 党真[1] 

机构地区：[1]黄淮学院附属医院心内科,河南驻马店463000

出　　处：《中国中西医结合急救杂志》2017年第2期166-169,共4页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：河南省重点科技攻关项目（122102310263,152102410004）;河南省驻马店市科技计划项目（12305）

摘　　要：目的观察山楂降脂散对高脂血症患者血脂的影响。方法选择2011年1月至2016年6月黄淮学院附属医院心内科收治的484例高脂血症患者，按随机数字表法分为观察组和对照组，每组242例。观察组服用山楂降脂散粉剂（山楂6g、丹参18g、黑豆16g、茯苓6g、灵芝9g、葛根6g、砂仁6g、山药9g、薏苡仁16g、决明子6g），每H早晚2次吞服，每次6～9g；对照组服用辛伐他汀，每次20mg，每晚餐时1次顿服；两组治疗周期均为2个月。比较两组治疗前后血脂及血清炎性因子水平的差异，观察两组淋巴细胞亚群变化并与本院同期淋巴细胞亚群正常且年龄在35—80岁的100例健康体检者进行比较，以及观察组和对照组总有效率、不良反应发生隋况和肝肾功能变化。结果观察组和对照组治疗前CD4^＋、CD8^＋、CD4^＋／CD8^＋比值均较健康对照组明显降低，但两组治疗后CD4^＋、CD8^＋、CD4^＋／CD8^＋比值均较治疗前升高，且以观察组的变化较对照组更显著（CD4^＋：0．47±0．11比0．40±0．10，CD8^＋：0．28±0．10比0．26±0．08，CD4^＋／CD8^＋：1．67±0．79比1．53±0．45）；两组治疗后超敏C-反应蛋白（hs—CRP）、白细胞介素-6（IL-6）、血管性血友病因子（vWF）、同型半胱氨酸（Hcy）均较治疗前明显降低，且观察组hs—CRP、IL-6、vWF明显低于对照组[hs—CRP（mg／L）：5．1±1．8比5．8±1．7，IL-6（ng／L）：2．9±1．6比3．7±1．8，vWF：（126．8±12．8）％比（156．5±11.3）％，均P〈0．05]。治疗后观察组Hcy较对照组有所降低，但两组比较差异无统计学意义（μmol／L：5．2±1．8比5．4±2．6，P〉0．05）。观察组治疗后各时间点总胆固醇（TC）、三酰甘油（TG）和低密度脂蛋白胆固醇（LDL—C）均治疗前明显降低，高密度脂蛋白胆固醇（HDL—C）和高密度脂蛋白，总胆固醇（HDL／TC）均较治疗前明显升高；Objective To observe the effect of Hawthorn Jiangzhi powder on blood lipids in hyperlipidemia patients. Methods Four hundreds and eighty-four patients with hyperlipidemia were selected from Department of Cardiology in Huanghuai University Affiliated Hospital from January 2011 to June 2016, and they were divided into observation group and control group by random number table, each group 242 cases. The observation group took orally Hawthorn Jiangzhi powder （including ingredients： hawthorn 6 g, salvia mihiorrhiza 18 g, black soybean 16 g, hoelen 6 g, ganoderma lucidum 9 g, kudzuvine root 6 g, Chinese yam 6 g, frnctus amomum 9 g, coix seed 16 g, cassia seed 6 g） once 6 - 9 g powder, twice a day, once in the morning and another in the evening; the control group was given simvastatin, 20 mg each day during taking dinner; the therapeutic period lasted 2 months in both groups. The differences in serum lipid and serum inflammatory factor levels were compared before and after treatment in the two groups; the changes of lymphocyte subsets of the two groups were observed and compared with the changes of the subset results of 100 normal heahhy subjects aged 35 - 80 years old in the same period in our hospital, and the total efficiency, the situations of adverse reactions and liver and kidney functions of two groups were observed. Results In the observation group and the control group, before treatment the levels of CD4^＋, CD8^＋, CD4^＋/CD8^＋ were lower than those of healthy control group, but after treatment the levels of CD4^＋, CD8^＋ and CD4^＋/CD8^＋ were higher than those before treatment, and the changes of the observation group were more significant than those of the control group（CD4^＋： 0.47 ± 0.11 vs. 0.40 ± 0.10, CD8^＋： 0.28 ± 0.10 vs. 0.26 ± 0.08, CD4^＋/CD8^＋： 1.67 ± 0.79 vs. 1.53 ± 0.45）; After treatment, the levels of hypersensitiveC-reactive protein （hs-CRP）, interleukin-6 （IL-6）, yon Willebrand factor （vWF） and homocysteine （Hey） in the two groups were si

关 键 词：山楂降脂散 血脂代谢 动脉粥样硬化 

分 类 号：R589.2[医药卫生—内分泌]