消退素在炎症相关疾病中减轻炎症反应的作用机制  

Mechanism of resolvins in reducing the inflammation reaction in inflammatory diseases

作　　者：崔术楠[1] 姚尚龙[2] 尚游[3] 

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉与重症医学研究所,湖北武汉430022 [2]华中科技大学同济医学院附属协和医院麻醉科,湖北武汉430022 [3]华中科技大学同济医学院附属协和医院ICU,湖北武汉430022

出　　处：《中华危重病急救医学》2017年第4期373-376,共4页Chinese Critical Care Medicine

基　　金：国家自然科学基金（81372036）

摘　　要：炎症反应是机体抵抗外界感染及损伤的一种重要机制.在正常条件下,适度的炎症反应有利于受损细胞及组织的修复,在促进机体恢复内环境稳态的过程中发挥重要作用;但当机体免疫功能受损时,局部急性炎症不能自行消退,此时过度的炎症反应会造成自身组织的非特异性损伤,从而引起各种炎症相关疾病的发生.消退素是一类具有促炎症消退作用的新型多不饱和脂肪酸衍生物,在急性炎症反应期,其作为机体内源性产生的小分子脂质介质,可以限制炎症过度发展并促进炎症及时消退,有利于受损组织的修复.深入探讨消退素减轻脓毒症和急性肺损伤（ALI）炎症反应的作用机制,有助于我们进一步了解炎症反应这一复杂过程,为重症加强治疗病房（ICU）常见炎症相关疾病的治疗提供新的方法,以降低患者病死率.Inflammation is an important mechanism for the host to resist external infection and injury. Under normal conditions, adaptive inflammatory response not only is conducive to the repair of damaged cells and tissues, but plays an important role to promote the internal environment to restored homeostasis. However, when the immune function is damaged, the unresolved and uncontrolled inflammation will cause non-specific tissue damage, which is linked to a variety of inflammatory diseases. In the acute inflammation, resolvins, a group of endogenous small molecular lipid mediators which are biosynthesized by polyunsaturated fatty acids, possess anti-inflammatory and pro-resolving actions, which are benefit for the repair of damaged tissue. Therefore, it is helpful to deeply explore the mechanisms of resolvins in inflammation-resolution phases of acute lung injury （ALI） and sepsis, which are favor of understanding the complex processes and provide new treatment for the inflammatory diseases thereby reducing the mortality in the intensive care unit （ICU）.

关 键 词：消退素 炎症 急性肺损伤 脓毒症 

分 类 号：R459.7[医药卫生—急诊医学]