电热针防治含顺铂方案化疗所致恶心呕吐:随机对照试验  

Electrothermal acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting:a randomized controlled trial

作　　者：芦殿荣[1] 芦殿香[2] 柏大鹏 何生奇[1] 王芳[1] 高音[1] 杜艳林[1] 王宁军[1] 江正龙[1] 王泽民[1] 朱世杰[1] 

机构地区：[1]中国中医科学院望京医院肿瘤科,北京100102 [2]青海大学医学院高原医学研究中心 [3]北京房山中医院肿瘤科

出　　处：《中国针灸》2017年第4期355-359,共5页Chinese Acupuncture & Moxibustion

基　　金：中国中医科学院院级课题自由探索项目:ZZ 0708089;望京医院院级课题:WJYY2014-YY-057

摘　　要：目的:观察电热针防治含顺铂方案化疗癌症痰瘀互阻型患者化疗所致恶心呕吐的有效性和安全性。方法:将60例含顺铂方案化疗的癌症痰瘀互阻型患者随机分为试验组和对照组,每组各30例。对照组采用盐酸格拉司琼3mg,顺铂化疗前以及顺铂化疗后30min静脉滴注,连续3d。试验组在对照组治疗基础上联合电热针治疗,于顺铂化疗前30min,电热针针刺足三里,通电并调节温至43~45℃,持续治疗30min,每日1次,连续3d。观察顺铂化疗第1d和第7d两组患者的化疗相关恶心呕吐(CINV)、止呕疗效、卡氏评分、痰瘀互阻证证候积分及相关安全性指标。结果:(1)CINV和止呕疗效:化疗前两组患者均无恶心呕吐,化疗第1d和第7d,两组患者出现恶心呕吐情况,试验组轻于对照组(均P<0.05),试验组止呕疗效均优于对照组;(2)卡氏评分与痰瘀互阻证证候积分:试验组于化疗第7d改善程度优于对照组,差异有统计学意义(均P<0.05);(3)安全性指标:治疗期间无不良反应发生。结论:电热针能够有效缓解含顺铂化疗方案患者化疗后的恶心呕吐,能够改善其生活自理状况,缓解其痰瘀互阻症状体征。Objective To observe the effectiveness and safety of electrothermal acupuncture in the prevention and treatment of chemotherapy-induced nausea and vomiting（CINV）in the cancerous patients of phlegm-stasis interaction in cisplatin-containing chemotherapy.Methods Sixty cases of phlegm-stasis interaction in cisplatin-containing chemotherapy were randomized into a trial group and a control group,30 cases in each one.In the control group,the intravenous drip of granisetron hydrochloride injection was adopted,3 mg before and after cisplatincontaining chemotherapy 30 min,continuously for 3days.43 to 45 ℃ electrothermal acupuncture at zusanli（ST 36）for 30 min was used on the basis of the treatment as the control group in the trial group,once a day for3 days.CINV,anti-nausea effects,Karnofsky score,the syndrome score of phlegm-stasis interaction,and relevant indices of safety were observed on the 1st and 7th days of cisplatin-containing chemotherapy separately.Results 1.Regarding CINV and anti-nausea effect,CINV did not occur before chemotherapy in the patients of the two groups.On the 1st and 7th days of chemotherapy,CINV in the trial group were milder than those in the control group（both P〈0.05）.The anti-nausea effects in the trail group were better than those of the control group.2.Regarding Karnofsky score and the syndrome score of phlegm-stasis interaction,the improvements on the 7th days of chemotherapy in the trial group were better than those in the control group,indicating the significant differences（both P〈0.05）.3.Regarding the safety indies,there was no adverse reaction during the treatment in the two groups.Conclusion The electrothermal acupuncture effectively relieves CINV,and improves self-care dbility and the symptoms of phlegm-stasis interaction.

关 键 词：化疗相关恶心呕吐 电热针 顺铂 

分 类 号：R246.1[医药卫生—针灸推拿学]