何首乌饮片及其制剂所致肝损伤不良反应分析  

Analysis of Liver Damage Caused by Polygonum Preparations and Decoction Pieces

作　　者：常乙玲[1] 

机构地区：[1]江苏省泰州市人民医院,江苏泰州225300

出　　处：《中国药业》2017年第3期74-77,共4页China Pharmaceuticals

摘　　要：目的分析何首乌致肝损伤的原因,为临床合理用药提供参考。方法收集医院2014年至2015年有关何首乌饮片及其制剂所致肝损伤的病例,并结合检索、汇总中国知网中何首乌所致肝损伤的相关信息,分析何首乌产生肝损伤的特征和原因。结果医院和中国知网共检出204例病例,导致肝损伤与性别、年龄、家族史关系不大,大多数患者是超剂量服用,201例经保肝治疗后好转出院,1例转归不明,2例死亡。结论何首乌致肝损伤可能与其所含的蒽醌类化合物和鞣质有关,患者服用剂量与时间长短也有一定关系,故应合理用药,同时监测肝功能指标。Objective To analyze the cause of liver injury induced by Polygonum and provide reference for clinical rational drug use to reduce the incidence of serious adverse events. Methods The cases of liver damage related to preparations and decoction pieces of Polygonum in the hospital from 2014 to 2015 were collected. The characteristics？and causes of liver injury produced Polygonum were analyzed by combing with the information of liver injury induced by Polygonum in CNKI. Results 204 cases were collected in the hos-pital and CNKI. The reason of liver damage had little relationship with gender, age, family history. Most patients were overdosed, and 201 patients were improved and discharged, 1 case had unknown outcome, 2 died after treatment. Conclusion The liver injury caused by Polygonum may be related to the anthraquinone compounds and tannins contained in the patients. The dose and duration are also related to the liver injury. Thus, we should stick to rational drug use and monitor the liver function index.

关 键 词：何首乌 肝损伤 临床特征 化学成分 

分 类 号：R285.6[医药卫生—中药学] R288[医药卫生—中医学]