郁福来胶囊质量标准研究  

Quality Control Standard of Yufulai Capsules

作　　者：倪玉佳 瞿发林[1] 

机构地区：[1]中国人民解放军第102医院制剂中心,江苏常州213003

出　　处：《中国药业》2017年第4期16-19,共4页China Pharmaceuticals

基　　金：军队医疗机构制剂标准提高科研专项课题[13ZJZ16-3]

摘　　要：目的制订郁福来胶囊的质量控制标准。方法采用薄层色谱法对郁福来胶囊中贯叶金丝桃药材、金丝桃苷进行定性鉴别,并采用高效液相色谱法测定郁福来胶囊中金丝桃苷的含量。结果供试品色谱中,在与对照品贯叶金丝桃药材、金丝桃苷相应位置上有相同的斑点,且分离效果好;金丝桃苷进样量在0.173~1.73μg范围内与峰面积线性关系良好,r=0.999 9(n=6),平均加样回收率为99.65%,RSD=1.00%(n=6)。结论该研究中建立的定性和定量分析方法操作简便,结果准确可靠,可用于控制郁福来胶囊的质量。Objective To study the quality control standard of Yufulai Capsules. Methods Herba hyperici perforati and hyperoside in Yufulai Capsules were identified by thin-layer chromatogram（TLC）. An HPLC method was used for the determination of hyperoside in Yufulai Capsules. Results Herba hyperici perforati and hyperoside were separated from other components well. The linear ranges of hyperoside was 0. 173-1. 73 μg,r=0. 9999（n=6）. The average recovery of hyperoside was 99. 65%,RSD=1. 00% （n=6）. Conclusion The method is simple,sensitive and reliable,which can be applied in the quality control of Yufulai capsules.

关 键 词：郁福来胶囊 贯叶金丝桃 金丝桃苷 质量标准 

分 类 号：R284.1[医药卫生—中药学]