近8年医院药品不良反应报告分析  

Analysis of Adverse Drug Reaction Reports in the Hospital for 8 Consecutive Years

作　　者：莫国栋 杨瑾 卢志军 翁舜龙 李嘉良 

机构地区：[1]广东省中山市第二人民医院,广东中山528400

出　　处：《中国药业》2017年第4期85-88,共4页China Pharmaceuticals

摘　　要：目的回顾性分析医院连续8年的药品不良反应(ADR),并结合广东省药品不良反应监测情况,为医院临床安全合理用药提供参考。方法收集医院2009年至2016年918例ADR报告,分别从患者性别、年龄、给药途径、临床表现等方面进行分析评价,并针对评价情况采取相应的药品安全性风险控制措施。结果 918例ADR报告中,男性患者居多,占66.88%;12~60岁患者ADR发生率高,有607例,占66.12%;口服药物ADR发生率较其他给药途径的发生率高,有362例,占39.43%;抗结核药物ADR发生率位居首位,有569例,占61.98%;ADR的临床表现以肝功能损害最常见,有302例,占32.90%;经对症治疗患者均转归良好。结论应继续加强医院ADR的报告及监测工作,确保临床用药的合理性和安全性。Objective To retrospectively analyze the adverse reactions induced by drug in the hospital for 8 consecutive years,and to provide a basis for clinical safety and rational drug use in combination with the monitoring of adverse drug reactions in Guangdong Province. Methods 918 cases of ADR were selected from 2009 to 2016,and the patients were analyzed and evaluated from the aspects of gender,age,route of administration and clinical manifestation. The corresponding drug safety risk control measures were taken for the evaluation. Results There were 607 cases of the male patients with ADR,accounting for 66. 88% in the total 918 cases. There were 607 cases （66. 12%）in the 12-60 years old patients. Adverse reactions were more in oral administration （362 cases,accounting for 39. 43%）than other routes;anti-TB drugs occurred the most adverse reactions with 569 cases （61. 98%）. ADR clinical manifestations of liver function damage was the most common with 302 cases （32. 90%）,which all went well after corresponding treatment. Conclusion The hospital should continue to strengthen the ADR report and monitoring work to ensure the rationality and safety of clinical medication.

关 键 词：药品不良反应 合理用药 回顾性分析 监测 

分 类 号：R969.3[医药卫生—药理学]