米非司酮联合米索前列醇终止早孕临床研究  

Clinical Study of Mifepristone Combined with Misoprostol in Termination of Early Pregnancy

作　　者：曹杰[1] 田立碧 杨森[1] 崔杰[1] 王佳[1] 

机构地区：[1]重庆医科大学附属大学城医院妇产科,重庆401331

出　　处：《中国药业》2017年第6期40-42,共3页China Pharmaceuticals

摘　　要：目的对比米非司酮联合米索前列醇口服与米非司酮联合卡前列甲酯栓(卡孕)阴道用药终止早孕(妊娠时间不超过49 d)的临床效果。方法选取2016年6月至11月收治的早孕患者140例,随机分为米非司酮联合米索前列醇组(A组)和米非司酮联合卡孕组(B组),各70例,对比两组患者服药后不良反应发生率、孕囊排除时间、流产成功率及流产后阴道流血时间。结果 A组中有69例完全流产,成功率为98.57%(69/70),B组中有63例完全流产,成功率为90.00%(63/70),两组差异有统计学意义(P<0.05);A组中有5例发生发热、腹泻等不良反应,其发生率为7.14%,B组中发生呕吐、腹泻等不良反应共2例,其发生率为2.86%,两组差异无统计学意义(P>0.05);孕囊排出时间A组为(4.2±1.6)d,B组为(6.3±3.1)d,两组差异有统计学意义(P<0.05);流产后平均阴道流血时间A组为(6.3±3.4)d,B组为(7.2±1.5)d,差异无统计学意义(P>0.05)。结论米非司酮联合米索前列醇口服比米非司酮联合卡孕终止早孕所用时间更短,成功率更高,二者不良反应及阴道流血时间长短差异不明显。Objective To compare the different clinical effect of Mifepristone combined with Misoprostol and Mifepristone combined with methylcarboprost on early pregnancy（〈 49 d） termination. Methods 140 patients diagnosed with early pregnancy in the hospital be- tween June 2016 and November 2016 were randomly divided into two groups,Mifepristone combined with Misoprostol was applied in group A（ n =70） and Mifepristone combined with Methylcarboprost was applied in group B（n =70）. Close follow-up of the incidence rate of adverse reactions, the time of the sac discharge, the success rate of abortion and the time of vaginal bleeding was taken. Results 69 cases in group A succeed in medical abortion,the success rate was 98.57% （69/70）;63 cases in group A succeed in medical abortion,the success rate was 90.00% （63/70）,the difference was significant（P 〈 O. 05）. 5 cases in group A suffered from adverse effect like fever and diarrhea,the incidence rate was 7.14% ;2 case in the group B suffered from vomiting and diarrhea,the incidence rate was 2.86% ,the difference was not significant（P 〉 0.05）. In group A,the gestational sac discharge time was（4.2 ＋ 1.6）d, the gestational sac discharge time of the B group was（6.3 ＋ 3. 1）d,and the difference was significant（ P 〈 O. 05）. In group A,the average time of vaginal bleeding after abortion was（6.3 ＋ 3.4）d, and the average vaginal bleeding time was （7. 2 ± 1.5）d in group B, and there was no significant difference between the two groups（ P 〉 0.05）. Conclusion Mifepristone combined with Misoprostol takes shorter time in terminating early pregnancy and ranks higher success rate compared with Mifepristone combined with Methylcarboprost; there is no difference in the drug adverse and the time of vaginal bleeding.

关 键 词：早孕 药物流产 米非司酮 米索前列醇 卡前列甲酯栓 

分 类 号：R969.4[医药卫生—药理学] R979.22[医药卫生—药学]