黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床研究  

Clinical trial of progesterone combined with nifedipine in the treatment of upper ureteral calculi

作　　者：黄色兰[1] 叶燕乐[1] 沈倚天[1] 

机构地区：[1]泉州市第一医院碎石中心,福建泉州362000

出　　处：《中国临床药理学杂志》2017年第7期592-594,共3页The Chinese Journal of Clinical Pharmacology

基　　金：泉州市卫生科研基金资助项目[泉卫函(2014)267号]

摘　　要：目的观察黄体酮注射液联合硝苯地平片治疗输尿管上段结石的临床疗效。方法将94例输尿管上段结石患者随机分为对照组47例与试验组47例。对照组给予盐酸消旋山莨菪碱注射液5~10 mg,qd,肌内注射;试验组在对照组的基础上给予黄体酮注射液20 mg,bid,肌内注射,硝苯地平片10 mg,tid,舌下含服。2组均治疗14 d。比较2组患者的临床疗效、治疗前后血清C-反应蛋白(CRP)、白细胞介素-6(IL-6)水平及药物不良反应发生情况。结果治疗后,试验组和对照组的总有效率分别为95.74%(45/47例)和82.98%(39/47例),差异有统计学意义(P<0.05)。治疗后,试验组和对照组的CPR分别为(2.17±0.25),(3.45±0.42)mg·L(-1);IL-6分别为(4.72±0.51),(8.34±0.89)ng·L^(-1),差异均有统计学意义(P<0.05)。试验组主要药物不良反应为口干、视物模糊、皮疹;对照组主要药物不良反应为口干、心跳加速、排尿困难以及皮疹,试验组和对照组的药物不良反应发生率分别为6.38%和10.64%,差异有统计学意义(P>0.05)。结论黄体酮联合硝苯地平治疗输尿管上段结石的临床疗效显著,安全性高。Objective To evaluate the clinical efficacy and safety of progesterone combined with nifedipine in the treatment of upper ureteral calculi.Methods A total of 94 patients with upper ureteral calculi were divided into control group and treatment group,47 cases in each group.Patients in control group were given anisodamine hydrochloride injection 5-10 mg by intramuscular injection,qd.Patients in treatment group received progesterone injection 20 mg by intramuscular injection,bid and nifedipine tablets 10 mg by under tongue,tid.All patients were treated for 14 d.The clinical efficacy,C-reactive protein（CRP）,interleukin-6（IL-6） and adverse drug reactions were compared between the two groups.Results The clinical efficacy in treatment group was 95.74%（45/47 cases）,had significant difference with that in control group,which was 82.98%（39/47 cases,P〈0.05）.The levels of CRP and IL-6 in treatment group were（2.17 ±0.25） mg · L^-1,（4.72 ±0.51） ng · L^-1,had significant difference with those in control group,which were（3.45 ± 0.42） mg · L^-1,（8.34 ± 0.89） ng · L^-1（P〈0.05）.The main adverse drug reactions in treatment group were dry mouth,blurred vision and rashes,the incidence rate was 6.38%（3/47 cases）.The main adverse drug reactions were dry mouth,rapid heart beat,difficulty urinating and rashes in control group,the incidence rate was 10.64%（5/47 cases,P〈0.05）.Conclusion Progesterone combined with nifedipine in the treatment of upper ureteral calculi was effective with high safety.

关 键 词：黄体酮 硝苯地平 输尿管上段结石 C-反应蛋白 白细胞介素-6 

分 类 号：R983[医药卫生—药品]