响应面法优化超声提取梅花鹿鹿茸多肽工艺  

Ultrasonic Extraction Technology Optimization of Pilose Antler Polypeptides by Response Surface Methodology

作　　者：于丽娜[1] 李峰[1] 张振秋[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600

出　　处：《辽宁中医药大学学报》2017年第4期37-39,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81073117)

摘　　要：目的:采用响应面法优化梅花鹿鹿茸多肽的提取工艺。方法:以鹿茸多肽含量为评价指标,通过单因素试验分别考察粉碎粒度、液料比和提取时间3个因素对多肽含量的影响,采用Box-Behnken的中心组合实验设计原理优化梅花鹿鹿茸多肽的提取工艺。结果:最佳提取工艺:粉碎粒度为80~100目,液料比为12,提取时间为40 min。结论:响应面法优化梅花鹿茸多肽提取工艺合理,具有较好的应用价值。Objective：To optimize the ultrasonic extraction technology of pilose antler polypeptides by response surface methodology. Methods：With the content of pilose antler polypeptides as the index,the effects of three factors including the particle size,the solvent-solid ratio and extraction time on the content of polypeptides were studied by single factor experiment,and the extraction technology was optimized by Box-Behnken design and response surface methodology. Results：The optimal extraction conditions were as follows：the particle size was 80-100 mesh,the solvent-solid ratio was 12 and the extraction time was 40 min. Conclusion：Optimizing extraction technology in pilose antler polypeptides by response surface methodology is reasonable,and the method has good application value.

关 键 词：鹿茸多肽 响应面法 提取工艺 

分 类 号：R284[医药卫生—中药学]