加味桂枝茯苓汤治疗肾虚血瘀型精索静脉曲张性不育患者疗效观察  

Clinical Observation of Modified Guizhi Fuling Tang for Varicocele Type Infertility Caused by Kidney Deficiency and Blood Stasis

作　　者：黄小庆[1] 苏劲松[1] 徐云森[1] 王晓文[2] 郭宇明[1] 严文兵[1] 吴江平[1] 龙云[1] 招活[1] 高荣芳[1] 

机构地区：[1]广州市中医医院,广州510130 [2]中山大学附属第三医院,广州510630

出　　处：《中国实验方剂学杂志》2017年第8期173-177,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2012]49号)

摘　　要：目的:观察加味桂枝茯苓汤治疗肾虚血瘀型精索静脉曲张性不育患者的临床疗效,并探讨其作用机制。方法:收集精索静脉曲张性不育患者,随机分为治疗组和对照组,治疗组口服加味桂枝茯苓汤治疗,对照组口服迈之灵治疗。两组共治疗3个月,治疗结束后随访3个月。比较两组患者临床疗效、精液质量、精索静脉管径、血清性激素水平变化,随访观察患者配偶受孕情况。结果:治疗组临床总有效率84.78%,对照组为67.50%,治疗组临床疗效优于对照组(P<0.05)。两组患者治疗后精子密度、精子活动力均比治疗前提高(P<0.05),且治疗组治疗后精子密度、精子活动力优于对照组(P<0.05)。两组治疗后精索静脉管径均较治疗前缩窄(P<0.05)。两组治疗后血清卵泡刺激素(FSH)明显下降,睾酮(T)明显上升(P<0.05),其中,治疗组T升高明显优于对照组(P<0.05);两组治疗后LH无明显变化。结论:加味桂枝茯苓汤可改善肾虚血瘀型精索静脉曲张性不育患者的精液质量,缩窄曲张静脉管径,调节生殖相关激素水平,改善生精功能。Objective： To observe the clinical efficacy of modified Guizhi Fuling Tang for varicocele type infertility caused by kidney deficiency and blood stasis, and investigate its mechanism. Method： The 86 patients with varicocele type infertility were randomly divided into treatment group （46 cases） and control group （40 cases）. Patients in treatment group were treated with modified Guizhi Fuling Tang, and patients in control group took aescuven forte. Both groups were treated for 3 months, and the patients were followed up for 3 months after the end of the treatment. The clinical efficacy, changes of sperm quality, spermatic vein diameter, and sex hormone levels after the treatment were compared between two groups, meanwhile the pregnancy results of their spouses were observed. Result： The total effectiveness was 84.78% in treatment, higher than 67.50% in control group （P 〈 0.05）. The sperm density and sperm motility were improved after treatment in both groups （P 〈 0.05）. After

关 键 词：精索静脉曲张性不育 肾虚血瘀 加味桂枝茯苓汤 迈之灵 疗效观察 

分 类 号：R277.5[医药卫生—中医学] R287