中药植物多糖对2型糖尿病胰岛素抵抗的作用机制研究进展  

Effect of Traditional Chinese Medicine Polysaccharides in Resisting Type 2 Diabetes Insulin

作　　者：孟祥云[1] 郭树明[1] 杨丽霞[2] 

机构地区：[1]甘肃省中医院,兰州730050 [2]甘肃省中医药研究院,兰州730050

出　　处：《中国实验方剂学杂志》2017年第8期220-225,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81202971);甘肃省中医药管理局科研项目(GZK-2016-48)

摘　　要：胰岛素抵抗(insulin resistance,IR)是2型糖尿病的重要病理生理机制,对胰岛素抵抗的治疗成为防治2型糖尿病的关键。目前,防治2型糖尿病,已经从降糖为主发展到利用胰岛素抵抗为靶点的综合治疗策略。中药多糖对改善2型糖尿病胰岛素抵抗具有良好的疗效,与西药治疗糖尿病胰岛素抵抗相比,中药多糖具有安全、疗效好、价格低的优势。但对其作用机制还缺乏科学系统的归纳。本文应用计算机中国知网数据库(CNKI),检索关键词"2型糖尿病,多糖,胰岛素抵抗",纳入全部有关中药植物多糖治疗糖尿病的文献,进行分析、归纳、总结。目的对中药多糖治疗2型糖尿病胰岛素抵抗的作用机制作一简要综述,希望为今后有关中药植物多糖种类、中药剂量以及服用时间等研究提供参考依据,开发出服用更便捷,疗效更好,更安全的新制剂。Insulin resistance （IR） is an important pathophysiological mechanism of type 2 diabetes. Treatment of IR becomes the key to prevent and treat type 2 diabetes. At present, the prevention and treatment of type 2 diabetes have developed from hypoglycemic therapy as the main purpose into comprehensive treatment strategy with insulin resistance as the target. Traditional Chinese medicine （TCM） polysaccharide has a good curative effect in improving IR of type 2 diabetes mellitus. Compared with western medicine for treating IR of type 2 diabetes mellitus, TCM polysaccharide has higher safety, good curative effect andlow price. However, there is no scientific and systematic summarizationfor the mechanisms of TCM polysaccharide on type 2 diabetes IR. In this paper, CNKI database was retrieved with ＇ polysaccharide, type 2 diabetes, insulin resistance＇ as key words to collect, analyze and summarize all of literatures of TCM polysaccharides in treatment of diabetes, in order to summarize effects and mechanisms of TCM polysaccharides for treating type 2 diabetes, provide reference for future studies related to polysaccharide species, dosage of TCM and taking time, and developed new preparations with a higher convenience, bettercurative effect and higher safety.

关 键 词：多糖 2型糖尿病 胰岛素抵抗 

分 类 号：R285[医药卫生—中药学]