Two new steroidal saponins isolated from Anemarrhena asphodeloides  

作　　者：SUN Xing-Huan ZHU Fu-Tao ZHANG Yu-Wei CHEN Fang-Fang YU Yun SONG Ning-Ning HUANG Xue-Feng 

机构地区：[1]State Key Laboratory of Natural Medicines,Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China

出　　处：《Chinese Journal of Natural Medicines》2017年第3期220-224,共5页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81573560);the National Training Programs of Innovation and Entrepreneurship for Undergraduates(No.G12123)

摘　　要：Two new steroidal saponins,named timosaponin P(1) and timosaponin Q(2),were isolated from the rhizome parts of Anemarrhena asphodeloides Bunge using various chromatographic methods.Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric data,including 1D,2D NMR,HR-ESI-MS and ECD calculations,and this is the first time the absolute configuration of C-23 of steroidal saponin was confirmed by ECD calculations.Two new steroidal saponins, named timosaponin P （1） and timosaponin Q （2）, were isolated from the rhizome parts afAnemarrhena asphodeloides Bunge using various chromatographic methods. Their structures and absolute configurations were elucidated by a combination of spectroscopic and spectrometric data, including 1D, 2D NMR, HR-ESI-MS and ECD calculations, and this is the first time the absolute configuration of C-23 of steroidal saponin was confirmed by ECD calculations.

关 键 词：Anemarrhena asphodeloides Timosaponin P Timosaponin Q ECD Steroidal saponin Absolute configuration 

分 类 号：R284[医药卫生—中药学]