西格列汀联合金匮肾气丸对2型糖尿病伴心脑血管病变患者血清Hcy、纤维蛋白原及细胞炎症因子水平影响研究  

Study on Effect of Serum Hcy,Fibrinogen and Inflammatory Cytokines in Patients with Type 2 Diabetes with Cardiac and Cerebral Vascular Diseases by Sitagliptin and Jinkui Shenqi Pill

作　　者：常绍菊 孟宪杰 李莉 曹丽慧 李会 

机构地区：[1]唐山人民医院心内科,河北唐山063000 [2]唐山人民医院内分泌科,河北唐山063000

出　　处：《辽宁中医杂志》2017年第4期800-803,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探讨西格列汀联合金匮肾气丸对2型糖尿病伴心脑血管病变患者血清Hcy、纤维蛋白原及细胞炎症因子水平的影响。方法:选取本院诊断并治疗的2型糖尿病伴心脑血管病患者96例,按随机数字表法分组,对照组48例予以常规治疗,研究组48例予以西格列汀联合金匮肾气丸治疗,检测并记录血糖状况、炎症因子及血清Hcy、纤维蛋白原、血液流变学状况,同时对比临床疗效及不良反应状况。结果:对照组临床有效率77.08%与研究组临床有效率91.67%数据对比,有显著性差异(P<0.05);相对于治疗前,两组治疗后FBG、2 h PBG、FINS及Hb Alc含量降低,治疗后炎症因子及血清Hcy、纤维蛋白原含量均降低,治疗后全血黏度、血浆黏度及ESR均降低,有显著性差异(P<0.05);相对于对照组,研究组治疗后FBG、2 h PBG、FINS及Hb Alc含量较低,治疗后炎症因子及血清Hcy、纤维蛋白原含量较低,治疗后全血黏度、血浆黏度及ESR较低,有显著性差异(P<0.05)。结论:西格列汀联合金匮肾气丸能降低2型糖尿病伴心脑血管病变患者血清Hcy、纤维蛋白原及细胞免疫因子水平,效果显著。Objective：To investigate the effect of serum Hcy,fibrinogen and inflammatory cytokines in patients with type 2 dia- betes with cardiac and cerebral vascular diseases by Sitagliptin and Jinkui Shenqi Pill. Methods ： A total of 96 cases of our hospital diagnosed with cardiac and cerebral vascular disease were randomly divided into two groups. Forty - eight cases in the control group were treated with conventional therapy and 48 cases in the experiment group were treated on the base of the control group with Sitagliptin and Jinkui Shetuli Pill. Blood glucose status, inflammatory cytokines and serum Hcy, fibrinogen and blood theolo- gy, and the clinical efficacy and adverse reaction conditions were compared. Results ： The clinical effency rate in the control group （77.08%） was lower than the experiment group＇s （91.67%） with significant difference （P 〈 0. 05 ）. Compared with the control group,levels of FBG ,2 hPBG, FINS and HbAlc in the experiment group were lower,the whole blood viscosity, plasma viscosity and ESR were significantly lower with significant difference （P 〈 0. 05 ）. Conclusion ： Sitagliptin combined with Jingui Shenqi Pill can reduce type 2 diabetes with cardiovascular and vascular pathological changes of serum Hcy, fibrin and cellular immune factor levels. The effect is remarkable.

关 键 词：西格列汀 金匮肾气丸 2型糖尿病 心脑血管病变 血清HCY 纤维蛋白原 炎症因子 

分 类 号：R587.1[医药卫生—内分泌]