2009～2015年中国山西省发热伴出疹症候群病毒性病原谱流行特征  

Viral Pathogenic Spectrum and Epidemiological Features of Rash and Fever Syndrome in Shanxi Province,China,during 2009～2015

作　　者：邱琪[1] 柴志凯[2] 郜慧[2] 任斌知[2] 常少英[2] 许文波[1] 王英[1] 崔爱利[1] 

机构地区：[1]中国疾病预防控制中心病毒病预防控制所卫生部医学病毒与病毒病重点实验室,北京102206 [2]山西省疾病预防控制中心,太原030012

出　　处：《病毒学报》2017年第2期169-175,共7页Chinese Journal of Virology

基　　金："十一五"和"十二五"国家科技重大专项(项目号:2009ZX10004201;2009ZX10004202;2012ZX10004201;2013ZX10004202);题目:"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项传染病监测技术平台项目

摘　　要：本研究通过对中国山西省2009~2015年哨点医院所采集的发热伴出疹症候群(Rash and fever syndrome,RFS)监测病例中六种病毒性病原体(麻疹病毒,风疹病毒,肠道病毒,水痘-带状疱疹病毒,人类小DNA病毒B19和登革病毒)进行描述性流行病学研究,阐明RFS在人群和时间的分布特点,揭示山西省2009~2015年RFS六种病毒病原谱构成及其流行规律,为山西省进一步开展RFS的预防和控制工作提供科学依据。在2009年1月1日至2015年12月31日期间,山西省共检测RFS监测病例846例,检出RFS病毒性病原阳性病例504例,阳性率为59.57%。其中麻疹病毒阳性192例(38.10%),肠道病毒阳性93例(18.45%),风疹病毒阳性87例(17.26%),水痘-带状疱疹病毒阳性83例(16.47%),人类小DNA病毒B19阳性48例(9.52%),登革病毒阳性1例(0.20%)。RFS阳性病例主要集中在15岁以下的儿童和学生,不同性别之间病原检出率无统计学差异,但不同年龄组的病原谱构成略有差异。RFS发病呈现出明显的季节性,3~8月为其发病高峰。监测数据提示我国应加强RFS系统性和连续性监测,将15岁以下的儿童和青少年作为重点监测人群,不同省份和地市可根据实际发病情况制定出具体的、有针对性的监测方案,以阐明本省或本地区RFS病毒病原的构成及其流行规律和疾病负担。A descriptive epidemiological study was done based on the surveillance data of rash and fever syndrome（RFS）in Shanxi Province,China,during 2009-2015. We analyzed the epidemiological characteristics and clarified the pathogenic spectrum of six viral pathogens among RFS cases：measles virus（MV）,rubella virus（RV）,enterovirus（EV）,varicella zoster virus（VZV）,human parvovirus virus B19（B19）and dengue virus（DENV）.This strategy helped to provide a scientific basis for further prevention and control of RFS in Shanxi Province.From 1January 2009 to 31December 2015,846 RFS cases were detected in Shanxi Province.Among them,504 cases were identified as being virus-positive and the total prevalence of virus-positive was≤59.57%.The prevalence of positive cases was 192（38.1%）for MV,93（18.45%）for EV,87（17.26%）for RV,83（16.47%）for VZV,48（9.52%）for B19 and 1（0.20%）for DENV.Most RFS cases were concentrated in those under 15 years of age.There was no significant difference between the prevalence of virus-positive cases between males and females,but there was a slight difference in the pathogenic spectrum among the different age groups of RFS cases.The number of RFS cases reached a peak from March to August.Based on RFS surveillance data,RFS surveillance should focus on those aged〈 15years.Systematic and continuous surveillance of RFS is crucial to prevent and control RFS.Moreover,a specific surveillance program in different areas could illuminate the spectrum of viral pathogens,epidemiological features and burden of RFS.

关 键 词：发热伴出疹症候群 病毒性病原谱 流行病学 

分 类 号：R373.9[医药卫生—病原生物学]