结直肠癌患者辅助化疗期中医证候分布观察  

Study on Chinese Medical Syndrome Distribution in Adjuvant Chemotherapy Period of Colorectal Cancer

作　　者：李妍[1,2] 邹莹[1] 谷建钟[2] 周华妙[2] 郭勇[2] 

机构地区：[1]浙江中医药大学第一临床医学院,杭州310053 [2]浙江中医药大学附属第一医院肿瘤内科,杭州310006

出　　处：《中国中西医结合杂志》2017年第4期414-418,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：浙江省科技厅公益技术应用研究社会发展项目(No.2010C33140);浙江省中医药管理局重点项目(No.2007ZA007)

摘　　要：目的观察结直肠癌患者辅助化疗期中医证候分布。方法收集160例结直肠癌患者辅助化疗前、化疗早期、化疗中期、化疗末期4个阶段的中医临床证候资料,分析4个阶段证候分布规律及动态变化。结果辅助化疗前有14个证候作为变量进行聚类分析,100例患者以阴虚内热夹湿证(40例,40.0%)、气虚证(30例,30.0%)为主。辅助化疗早期有16个证候作为变量进行聚类分析,120例患者以脾虚血亏证(60例,50.0%)、阴虚内热证(45例,37.5%)为主。辅助化疗中期有22个证候作为变量进行聚类分析,114例患者以肝热脾虚证(51例,44.7%)、气血两虚证(40例,35.1%)、脾虚夹湿证(19例,16.7%)为主。辅助化疗末期有24个证候作为变量进行聚类分析,110例患者以虚证为主,包括气血两虚证(32例,29.1%)、脾虚证(29例,26.4%)、肝肾阴虚证(49例,44.6%)。结论结直肠癌辅助化疗期中医证候以虚证为主。Objective To study the Chinese Medical （CM） syndrome distribution in patients with colorectal cancer in adjuvant chemotherpay period. Methods Totally 160 patients with colorectal cancer were recruited and clinical data for the CM syndromes before receiving adjuvant chemotherapy, in the early, mid and after period of adjuvant chemotherapy were collected. The distribution and dynamic chan- ges of CM syndromes were observed. Results The primary CM syndrome before chemotherapy were yin deficiency induced inner heat with dampness（40 cases, 40.0%） and qi deficiency syndrome（30 cases ,30.0%） concluded by 14 symptoms during cluster analyses among 100 cases.The primary CM syn- drome at the early period of adjuvant chemotherapy was Pi and blood deficiency syndrome （60 cases, 50.0%）, closely followed by syndrome of yin deficiency induced inner heat（45 cases, 37.5%） by 16 symptoms during cluster analyses among 120 cases. The CM syndrome at the mid period of adjuvant chemotherapy consisted of syndrome of Gan-heat and Pi-deficiency （51 cases,44.7% ）, syndrome of qi and blood deficiency （40 cases,35.1%）, as well as Pi-deficiency with dampness syndrome （19 cases, 16.7%） by 22 symptoms during cluster analyses among 114 cases; at the period after adjuvant chemo- therapy, the major CM syndromes was deficiency syndrome, including qi and blood deficiency syndrome （32 cases ,29.1% ）, Pi-deficiency syndrome（29 cases,26.4%） and Gan-Shen yin deficiency syndrome （49 cases,44.6%） by 24 symptoms during cluster analyses among 110 cases. Conclusion During the period of adjuvant chemotherapy in colorectal cancer patients, the mainly CM syndromes shows the defi- ciency syndrome.

关 键 词：结直肠癌 辅助化疗期 中医证候 聚类分析 

分 类 号：R273[医药卫生—中西医结合]