MicroRNA对缺血再灌注损伤的调控作用  

Regulatory Effect of MicroRNAs on Ischemia Reperfusion Injury

作　　者：杨艺[1] 张富春[1] 

机构地区：[1]新疆生物资源基因工程重点实验室,新疆大学生命科学与技术学院,乌鲁木齐830046

出　　处：《中国生物化学与分子生物学报》2017年第4期324-330,共7页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金-新疆联合基金重点项目(No.U1403223)~~

摘　　要：MicroRNA(miRNA)是一类小的(~20个核苷酸)、非编码的单链RNA分子,能够负调控基因表达,涉及多种信号途径和病理生理过程。缺血再灌注损伤(ischemia reperfusion injury,IRI)指组织器官缺血后重新获得血液的再灌注过程,灌注后组织、器官功能不能恢复,造成功能障碍和结构损伤的现象。IRI是影响多个组织与器官复杂的、系统的生理病理过程,并能够产生很多不可逆的损伤,导致级联的多器官功能障碍。现已发现多种miRNA在组织器官IRI中发生明显的变化,表明miRNA能够直接或者间接影响组织器官IRI。本文综述了miRNA的靶基因以及在心、脑、肝和肾IRI中的调控作用。miRNA不仅参与了器官IR损伤的病理生理过程,而且作为IR损伤的特定标志物在临床诊断和干预治疗中具有广阔的前景。MicroRNAs （miRNAs） are the endogenous non-encoding small RNA molecules that regulate gene expression and participate in important cellular pathways as well as various physiological and pathological processes. Ischemia reperfusion injury （IRI） refers to the blood reperfusion process of tissues and organs after ischemia. The function of the IRI tissues and organs cannot be restored after perfusion which results in dysfunction and structural damage. IRI is a complex systemic process that affects multiple tissues and organs and causes irreversible damage which leads to a cascade of dysfunction of multiple organs. It has been found that a variety of miRNA has obvious expression changes in tissues and organs of IRI, indicating that miRNA can directly or indirectly affect IRI tissues and organs. This review is to provide insights into the regulatory role of miRNA in the IRI of the heart, brain, liver and kidney. MiRNA is not only involved in the pathophysiological process of organ IRI, but also plays a crucial role in clinical diagnosis and intervention treatment as a specific marker of IRI.

关 键 词：MICRORNA 缺血再灌注损伤 心 脑 肝 肾 

分 类 号：R617[医药卫生—外科学]