小囊网盘衣真菌新色原酮类次级代谢产物初步研究  

A preliminary study of the isoprenylated chromones from lichenized fungus Sarcogyne asciparva

作　　者：王娇红 李二伟[1] 魏江春[1,2] 

机构地区：[1]中国科学院微生物研究所真菌学国家重点实验室,北京100101 [2]中国科学院大学,北京100049

出　　处：《菌物学报》2017年第4期492-502,共11页Mycosystema

基　　金：国家自然科学基金(31470149)~~

摘　　要：地衣是地衣型真菌与相应藻类或蓝细菌之间紧密而稳定的独特的共生生态系统。本实验以分离自小囊网盘衣中的地衣型小囊网盘衣真菌Sarcogyne asciparva为材料,通过液体深层培养后,从中分离到8个新色原酮类次级代谢产物Sarcasciols A–H(1–8),应用质谱和核磁共振技术确定了它们的结构,用改进Mosher′s方法确定了sarcasciol(1)中C-6位的绝对构型。并用96孔板法检测化合物的抑菌活性。Lichens are symbiotic ecosystem of mostly ascomycetous fungi（mycobiont） and photosynthetic partners（photobiont） which are either green algae or cyanobacteria. Using cultured separated lichenized fungus Sarcogyne asciparva as material, sarcasciols A–H（1–8）, eight new isoprenylated chromone derivatives have been isolated from scale-up culture. The structures of 1–8 were elucidated by mass spectra and nuclear magnetic resonance experiments. The absolute configuration of C-6 in 1 was assigned by application of the modified Mosher＇s method. The antibacterial activity of compounds 1–8 was revalued by 96-well plate method.

关 键 词：地衣型真菌 Sarcogyne asciparva 新色原酮类化合物 

分 类 号：Q949.34[生物学—植物学]