黑顶卷柏木脂素类化学成分研究  

Lignans from Selaginella picta Spring

作　　者：成飞[1,2] 邹振兴[1,2] 姚采平 张燕[2] 徐康平[2] 谭桂山[1,2] 

机构地区：[1]中南大学湘雅医院,长沙410008 [2]中南大学湘雅药学院,长沙410013

出　　处：《中南药学》2017年第2期146-149,共4页Central South Pharmacy

基　　金：国家自然科学基金项目(No.31370370;No.30873149)

摘　　要：目的研究卷柏属植物黑顶卷柏木脂素类化学成分。方法采用大孔吸附树脂、硅胶、Sephadex LH-20/HW-40C柱色谱及半制备高效液相等分离方法对黑顶卷柏75%乙醇提取物进行分离纯化,根据化合物的理化性质和波谱数据进行结构鉴定。结果从黑顶卷柏75%乙醇提取物中分离鉴定得到6个木脂素类化合物,分别为syringaresinol(1)、3,3',5-trimethoxy-4',7-epoxy-8,5'-neoligan-4',9,9'-triol(2)、4,9-dihydroxy-4',7-epoxy-8',9'-dinor-8,5'-neolignan-7'-oic acid(3)、(+)-isolariciresinol(4)、3-O-caffeoyl quinic acid methyl ester(5)、3,4-di-O-caffeoyl quinic acid methyl ester(6)。结论化合物1~6为首次从该植物中分离得到,其中化合物4和5为首次从卷柏属植物中分离得到。Objective To determine the chemical constituents in Selaginella picta Spring. Methods The com- pounds were isolated and purified from 75% aqueous ethanol extract of Selaginella picta by macroporous resin, silica gel, Sephadex LH-20/HW-40C, and Prep-HPLC chromatographic methods. Their structures were elucidated by physicochemical properties and spectroscopic methods. Results Six lignans were isolated from Selaginella picta, and identified as syringaresinol （1）, 3, 3＇, 5-trimethoxy-4＇, 7-epoxy-8, 5＇-neoligan-4＇, 9, 9＇-triol （2）, 4, 9-dihydroxy-4＇, 7-epoxy-8＇, 9＇-dinor-8, 5＇-neolignan-7＇-oic acid （3）, （ ＋ ）-isolariciresinol （4）, 3-O-caffeoyl quinic acid methyl ester （5）, and 3, 4-di-O-caffeoyl quinic acid methyl ester （6）. Conclusion Compounds 1 - 6 have been isolated from this plant for the first time and compound 4 and 5 from genus Selaginella for the first time.

关 键 词：卷柏属 黑顶卷柏 化学成分 结构鉴定 木脂素 

分 类 号：R284[医药卫生—中药学]