甘氨酸螯合亚铁治疗妊娠期缺铁性贫血的临床研究  

Treatment of iron deficiency anemia of pregnancy with ferrous glycinate

作　　者：姜海利[1] 李扬[1] 王小榕[1] 范玲[1] 张素云[1] 蔺莉[2] 路军丽[3] 王雅玲 谭萍 杜金洁[6] 

机构地区：[1]北京妇产医院产科,北京100026 [2]北京友谊医院,北京100050 [3]北京朝阳医院,北京100020 [4]北京顺义妇幼保健院,北京101300 [5]青岛医科大学附属医院,山东青岛266000 [6]无锡市妇幼保健院,江苏无锡214000

出　　处：《中国妇幼健康研究》2017年第3期294-295,308,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的探讨甘氨酸螯合亚铁治疗妊娠期缺铁性贫血的疗效及不良反应。方法采用多中心、前瞻性、病例对照的方法,202例缺铁性贫血的孕妇按门诊就诊号分为实验组(107例)和对照组(95例)。实验组给予甘氨酸螯合亚铁治疗,对照组给予多糖铁复合物治疗。治疗3个月,观察治疗前后患者的红细胞计数(RBC)、血红蛋白(Hb)、血清铁蛋白(SF)水平及不良反应的发生率。结果治疗3个月后,实验组的RBC(3.98±0.44)高于对照组(3.72±0.55),P=0.025;实验组的Hb(117.33±9.17)高于对照组(111.56±10.88),P=0.011;实验组SF为36.17,高于对照组的25.25,P=0.030。实验组出现1例胃肠道反应,对照组出现2例便秘,两组的不良反应比较无统计学意义。结论甘氨酸螯合亚铁可以治疗妊娠期缺铁性贫血,较多糖铁复合物更有效,并且未见增加不良反应率。Objective To investigate the curative effect and adverse reactions of ferrous glycinate（ Ai Me Iron） on treatment of iron deficiency anemia（ IDA） of pregnancy. Methods With multicenter,prospective and case-control method,altogether 202 pregnant women with IDA were divided into experimental group（ 107 cases） and control group（ 95 cases） based on outpatient service number. Patients in the experimental group were treated with ferrous glycinate and patients in the control group were treated with polysaccharideiron complex.After three months of treatment,red blood cell count（ RBC）,hemoglobin（ Hb）,serum ferritin（ SF） levels and incidence of adverse reactions of patients were observed before and after treatment. Results After three months of treatment,RBC in the experimental group（ 3. 98 ± 0. 44） was higher than that（ 3. 72 ± 0. 55） in the control group（ P = 0. 025）. Hb in the experimental group was 117. 33 ± 9. 17,which was significantly higher than that（ 111. 56 ± 10. 88） in the control group（ P = 0. 011）. SF in the experimental group was 36. 17,which was significantly higher than that（ 25. 25） in the control group（ P = 0. 030）. One case in the experimental group had gastrointestinal reactions,and constipation occurred in two cases in the control group. The difference in adverse reactions was not statistically significant between two groups. Conclusion Ferrous glycinate can be used in treatment of IDA of pregnancy,and it is more effective than polysaccharideiron complex without increase of adverse reaction.

关 键 词：妊娠期 缺铁性贫血 甘氨酸螯合亚铁 疗效 

分 类 号：R714.7[医药卫生—妇产科学]