莱克多巴胺在兔体内的药物动力学及生物利用度研究  

The Pharmacokinetics and Bioavailability of Ractopamine in Rabbits

作　　者：王见一 孙源泽[1] 彭涛[1] 王成[1] 谢洁[1] 张西亚[1] 江海洋[1] 

机构地区：[1]中国农业大学动物医学院,北京100193

出　　处：《中国兽药杂志》2017年第4期50-54,共5页Chinese Journal of Veterinary Drug

摘　　要：为了研究莱克多巴胺静脉注射和灌胃在兔体内的药动学特征和生物利用度,静脉注射和灌胃的给药剂量分别为10和20 mg·kg^(-1)。兔静脉注射莱克多巴胺溶液的药-时数据符合无吸收两室模型,主要药动学参数分别为T_(1/2α)为0.56±0.084 h、T_(1/2β)为7.20±0.59 h、AUC为8.04±2.32 h·μg·m L^(-1)。兔灌胃莱克多巴胺溶液的药-时数据符合一级吸收两室模型,主要药动学参数分别为TK01为0.72±0.07 h、T1/2α为0.72±0.11 h、T_(1/2β)为26.43±2.73 h、T_(max)为1.13±0.09 h、Cmax为1.29±0.08μg·mL^(-1)、AUC为3.98±0.43 h·μg·mL^(-1)。灌服莱克多巴胺溶液的绝对生物利用度F为24%。莱克多巴胺在兔体内的药动学特征是吸收迅速,分布广泛,消除缓慢,生物利用度低。The pharmacokinetics and bioavailability of intravenous （ 10 mg·kg^-1 ） , oral ractopamine were investigated in rabbits following single （20 mg·kg^-1） administration of ractopamine solution. The ractopamine concentration-time data were fitted to a two-compartment model after single intravenous administration of the ractopamine solution. The main pharmacokinetic parameters were as follows ： T1/2α 0.56±0.084 h, T1/2β 7.20 ± 0.59 h, AUC 8.04±2.32 h·μg·mL^-1. The ractopamine concentration-time data were described by a two- compartment model with first-order absorption after single oral administration of the ractopamine solution. The main pharmacokinetic parameters were as follows ： TK01 0.72±0.07 h, T1/2α 0.72 ± 0.11 h, T1/2β 26.43 ±2.73 h, Tmax 1.13±0.09 h, Cmax 1.29±0.08 μg·mL^-1, AUC 3.98±0.43 h·μg·mL^-1. The oral bioavailability of ractopamine solution was 24%. The pharmacokinetic characteristics of ractopamine in rabbit displayed rapid absorption, slow elimination and low bioavailability.

关 键 词：莱克多巴胺 药物动力学 兔 绝对生物利用度 

分 类 号：S859.79[农业科学—临床兽医学]