胃癌患者血清TSLP表达水平及临床意义  

The Expression Level and Clinical Significance of Serum TSLP in Patients with Gastric Cancer

作　　者：董虹[1] 黄蓉[1] 刘天春[1] 

机构地区：[1]长江大学第一临床医学院荆州市第一人民医院检验科,湖北荆州434000

出　　处：《长江大学学报（自然科学版）》2017年第8期40-43,共4页Journal of Yangtze University(Natural Science Edition)

摘　　要：目的:探讨胃癌患者血清胸腺基质淋巴细胞生成素(Thymic stromal lymphopoietin,TSLP)表达水平及临床意义。方法:收集医院(荆州市第一人民医院)2008年1月至2011年1月收治的100例胃癌患者临床资料,收集同期我院体检的100例健康人群作为对照组。采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)检测其血清TSLP表达水平,比较不同病理特征的胃癌患者血清TSLP表达水平以及不同血清TSLP表达水平患者的生存率,并采用Cox比例风险模型分析胃癌患者预后影响因素。结果:胃癌组患者血清TSLP表达水平(218.6±134.2pg/mL)显著高于非胃癌组患者(145.3±123.5pg/mL)(P<0.05);不同组织分化、淋巴结转移、肝转移以及临床分期的胃癌患者血清TSLP表达水平数据比较差异有统计学意义(P<0.05);Cox比例风险模型分析结果显示血清TSLP浓度影响胃癌患者预后(95%CI=1.000~1.002,P=0.003);血清低TSLP组患者5年生存率(51.7%)显著高于血清高TSLP组患者(21.5%)(P<0.05)。结论:胃癌患者血清TSLP表达水平显著增高,且血清TSLP高表达水平患者的预后较差,值得进一步深入研究。Objective:To investigate the expression level and clinical significance of serum TSLP in the patients with gastric cancer.Methods:100patients with gastric carcinoma had been selected in the First Hospital of Yangtze University from January 2008to January 2011as the study group and 100healthy subjects taking physical examination in the same period in the hospital had been selected as the control group.ELISA had been adopted to investigate the serum TSLP expression levels,which had also been compared among the gastric cancer patients with different pathological characteristics,the survival rates of the patients with different serum TSLP expression levels compared and the Cox proportional hazard model used to analyze the factors affecting the prognosis.Results:The serum TSLP expression levels of gastric cancer patients(21.86±13 4.2)pg/mL were significantly higher than those of healthy subjects(145.3±123.5)pg/mL(P<0.05);the data of serum TSLP expression levels of different histological differentiation,lymph node metastasis,liver metastasis and clinical staging of gastric cancer patients were statistically significant(P<0.05);Cox proportional hazard model analysis showed that serum TSLP concentrations affected the prognosis of the patients(95%CI 1.000~1.002,P=0.003);the 5-year survival rate of the patients with lower serum TSLP(70.5%)was significantly higher than those with the higher serum TSLP(50.6%)(P=0.027).Conclusion:The expression levels of serum TSLP in the patients with gastric cancer are significantly higher.The prognosis of patients with higher expression level of TSLP is poor,which is worth further study.

关 键 词：胃癌 TSLP 生存率 预后 

分 类 号：R416.63[医药卫生—临床医学]