中医辨证结合高效抗逆转录病毒治疗人类免疫缺陷病毒脑病临床研究  

Clinical study of the Chinese medicine syndrome differentiation combined with HAART for the acquried immune deficiency syndrom dementia complex

作　　者：张雪[1] 蒋自强[2] 陈丽华[2] 孙燕[1] 杨萱[1] 王双利[1] 安永辉[1] 张晓华[1] 焦敏[1] 张静[1] Zhang Xue Jiang Ziqiang Chen Lihua Sun Yan Yang Xuan Wang Shuangli An Yonghui Zhang Xiaohua Jiao Min Zhang Jing(Two Department of Infection Diseases, the Sixth People＇s Hospital of Zhengzhou, Zhengzhou 450000, Chin)

机构地区：[1]河南省郑州市第六人民医院感染二科,450000 [2]河南中医学院第一附属医院艾滋病临床研究中心,郑州450000

出　　处：《国际中医中药杂志》2017年第4期298-302,共5页International Journal of Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题（2014ZY02087）

摘　　要：目的 评价中医辨证结合高效抗逆转录病毒（highly active anti-retrovital therapy,HAART）治疗人类免疫缺陷病毒（human immunodeficiency virus,HIV）脑病的疗效.方法 将符合入选标准的80例HIV脑病患者采用随机数字表法分为2组,每组40例.对照组采用HAART治疗,治疗组在对照组基础上加用中药治疗,2组均治疗3个月.观察治疗前后中医证侯积分、简易精神状态检查表（mini mental state examination,MMSE）、日常生活能力量表（daily behavior scale,ADL）积分及HIV脑病临床分期的变化,评价临床疗效,记录不良反应.结果 治疗组总有效率为82.5%（33/40）、对照组为65.0%（26/40）,2组比较差异有统计学意义（χ2=8.115,P=0.024）.治疗后,治疗组ADL评分[（33.7±5.2）分比（37.7±5.3）分,t=2.528]低于同组治疗前（P〈0.05）,MMSE评分[（24.8±4.4）分比（20.0±5.5）分,t=1.006]高于同组治疗前（P〈0.05）;对照组ADL评分[（34.5±5.0）分比（37.0±5.5）分,t=2.747]低于同组治疗前（P〈0.05）,MMSE评分[（24.7±4.4）分比（20.1±4.9）分,t=1.035]高于同组治疗前（P〈0.05）.治疗后,治疗组临床1、2期HIV脑病患者分布与同期对照组比较,差异均无统计学意义（χ2值分别为1.231、2.726,P值分别为0.954、1.053）.结论 中医辨证结合HAART治疗可较好的改善HIV脑病患者的临床症状,疗效优于单纯西医治疗.Objecve To observe the clinical effect and safety of the Chinese medicine syndrome differentiation combined with HAART for the ADC（acquried immune deficiency syndrom dementia complex）. Methods A total of 80 patients with ADC were divided into the treatment group and control group based on random number table, 40 in each group. The patients in the control group were treated by highly active anti-retrovital therapy （HAART）. The patients in the treatment group were treated with TCM treatment on the based of the control group. Both groups received the treatment for 3 months.These outcomes were measured： TCM syndrome integral, mini mental state examination（MMSE）, daily behavior scale（ADL）, change of clinical stage, and adverse reactions. Results The effect rate of treatment group was 82.5%, which was significant higher than 65% of the control group （χ2=8.115,P=0.024）. After the treatment, the ADL integral of the treatment group （37.69 ± 5.31vs.33.67 ± 5.16;t=2.528,P=0.021） was significantly higher than that before the treatment; and the ADL integral of the control group（36.96 ± 5.52vs.34.54 ± 4.98;t=2.747,P=0.027） was significantly higher than that before the treatment.But there was no significant difference between the two groups after the treatment （t=2.003,P=0.139）. After the treatment, the MMSE integral of the treatment group （24.76 ± 4.43 vs.19.97 ± 5.46;t=1.006,P=0.013） was significantly higher than that before the treatment; the MMSE integral of the control group（24.65 ± 4.36 vs. 20.11 ± 4.87;t=1.035,P=0.014） was significantly higher than that before the treatment. But there was no significant difference between the two groups after the treatment （t=0.953, P=0.347）.There was no significant difference between the two groups in the clinical stage change （phase1χ2=1.231,P=0.954; phase2χ2=2.726,P=1.053）. There was no adverse reaction in the two groups during the treatment.Conclusions The Traditional Chinese medcine combined with HAART was better than HAAR

关 键 词：HIV 脑病 抗HIV药 辨证论治 临床研究 

分 类 号：R512.91[医药卫生—内科学]