2-烷硫基吡啶并[2，3-d]嘧啶衍生物的合成与除草活性  

Synthesis and Biological Activity of 2-Alkylthio-pyridio [2,3-d] pyrimidine Derivatives

作　　者：吴小盛 刘姝[1] 张可可[1] 王涛[1] 罗劲[1,2] WU Xiao-shen LIU Shu ZHANG Ke-ke WANG Taol LUO Jin(Jiangxi Province Key Laboratory of Chemical Biology, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Jiangxi 330022, China Analytical＆Testing Center, Jiangxi Normal University, Jiangxi 330022, China)

机构地区：[1]江西师范大学化学化工学院,江西省化学生物学重点实验室,江西南昌330022 [2]江西师范大学分析测试中心,江西南昌330022

出　　处：《精细化工中间体》2017年第1期36-40,46,共6页Fine Chemical Intermediates

基　　金：国家自然科学基金(21262018,21562026);江西省自然科学基金(20161BAB203085);江西省自然科学青年基金(20161BAB213072)

摘　　要：以4-氨基-5-氰基-2,6-二烷硫基嘧啶和乙酰乙酸乙酯为原料合成了10种未见文献报道的2-烷硫基-4-甲硫基-5-氨基-6-乙氧羰基-7-甲基吡啶并[2,3-d]嘧啶衍生物3a^3j。目标化合物的结构经~1H NMR、LC-MS、IR和元素分析表征确证。对单、双子叶植物的除草活性测试结果表明,在100 mg/L浓度下,目标化合物3a、3c和3f对稗草、油菜茎和根的生长表现出100%抑制活性。A novel series of 2-alkylthio-pyridio [2,3-d] pyrimidine Derivatives （3a -3j） were successfully synthesized from the reaction of 4-amino-5-cyan-2,6-dialkythio pyrimidine with ethyl aeetoaeetate under mild condition.The structures of the title compounds were fully characterized using elementary analysis, IR, 1H NMR and LC-MS. The results of preliminary bioassay demonstrated that compounds 3a, 3c and 3f showed excellent herbicidal activities on barnyard grass and rape at a dosages of 100 mg/L.

关 键 词：吡啶并[2 3-d]嘧啶衍生物 合成 除草活性 

分 类 号：O626.4[理学—有机化学]