2-(2-氯吡啶-4-基)-1H-苯并[d]咪唑的合成  

Synthesis of 2-(2-Chloropyridin-4-yl)-1H-benzo[d]imidazole

作　　者：吴丽聪[1] 苑贺 刘丹丹[1] 白梦轩 丁怀伟[1] 张丽娟[1] 宋宏锐[1] WU Li-cong YUAN He LIU Dan-dan BAI Meng-xuan DING Huai-wei ZHANG Li-juan SONG Hong-rui(Key Laboratory of Structure-Based Drug Design and Discovery （Shenyang Pharmaceutical University）, Ministry of Education, Shenyang 110016, China)

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《精细化工中间体》2017年第1期47-49,共3页Fine Chemical Intermediates

基　　金：辽宁省教育厅科学研究一般项目(L2015514)

摘　　要：以2-氯吡啶-4-甲酸为原料,与氯化亚砜回流制成酰氯,与邻苯二氨缩合制成酰胺,在冰乙酸中回流脱水环化得1H-2-(2-氯吡啶)-苯并[d]咪唑。目标化合物收率94.60%,其结构经1H NMR和GC-MS确证。2-Chloroisonicotinic acid refluxed with thionyl chloride to give 2-chloroisonicotinoyl chloride, then 2- chloroisonicotinoyl chloride reacted with benzene-l,2-diamine to obtain amide through a condensation reaction. The target compound was obtained through eyclodehydration by refluxing in acetic acid.

关 键 词：1H-苯并[d]咪唑 2-氯吡啶-4-甲酸 环化脱水 

分 类 号：TQ252.3[化学工程—有机化工]