血浆同型半胱氨酸水平与糖耐量减低患者周围神经病变的相关性研究  

Correlation between plasma homocysteine level and impaired glucose tolerance in patients with peripheral neuropathy

作　　者：李霞[1] 朱炬[1] 张哲成[1] 

机构地区：[1]天津市第三中心医院神经内科,天津市肝胆疾病研究所,天津市人工细胞重点实验室,卫生部人工细胞工程技术研究中心,300170

出　　处：《国际生物医学工程杂志》2017年第1期20-23,共4页International Journal of Biomedical Engineering

基　　金：天津市卫生行业重点攻关项目（14KG110）

摘　　要：目的 探讨血浆同型半胱氨酸水平与糖耐量减低（IGT）周围神经病变的相关性.方法 根据常规神经传导检测结果,选取IGT患者80例,其中40例伴有周围神经病变（IGT-PN）,40例无周围神经病变（IGT-NPN）,同时选取40名健康者作为对照.采用酶速率法分别对3组受试者进行血浆同型半胱氨酸水平检测,通过多伦多临床评分系统（TCSS）对神经病变的严重程度进行评分与分级.结果 研究对象中,IGT组血浆同型半胱氨酸水平均高于健康对照组.IGT-PN组血浆同型半胱氨酸水平为（14.2±2.7） μmol/L,显著高于IGT-NPN组的（12.3±2.6） μmol/L,其差异具有统计学意义（P〈0.05）.回归分析表明血浆同型半胱氨酸水平对IGT合并周围神经病变具有独立作用.血浆同型半胱氨酸水平与TCSS评分呈显著正相关.结论 血浆同型半胱氨酸可能具有促进IGT患者伴发周围神经病变的作用,其水平与IGT患者周围神经病变的严重程度相关.Objective To investigate the correlation between plasma homocysteine level and impaired glucose tolerance（IGT） patients in peripheral neuropathy.Methods 80 patients with IGT were selected according to the results of routine nerve conduction test,including 40 patients associated with peripheral neuropathy （IGT-PN）,and 40 patients without peripheral neuropathy （IGT-NPN）.Besides,40 healthy subjects were selected as control.Plasma homocysteine levels were measured in the three groups by enzyme rate method.The severity of neuropathy was scored and graded by the Toronto Clinical Scoring System （TCSS）.Results Plasma homocysteine levels were significantly higher in the all IGT groups than those in the control group.The plasma homocysteine level in the IGT-PN group （14.2±2.7） μmol/L was significantly higher than that in the IGT-NPN group （12.3±2.6） μmol/L （P〈0.05）.Regression analysis showed that plasma homocysteine level had independent effects on IGT with peripheral neuropathy.Plasma homocysteine level was positively correlated with TCSS score.Conclusions Plasma homocysteine may play an important role in the pathogenesis of peripheral neuropathy in patients with IGT,and their level may be associated with the severity of peripheral neuropathy.

关 键 词：同型半胱氨酸 糖耐量减低 周围神经疾病 多伦多临床评分系统 

分 类 号：R587.2[医药卫生—内分泌]