超声射频评价2型糖尿病合并微量白蛋白尿患者股动脉弹性早期改变  

Evaluation of early changes of femoral artery elasticity in type 2 diabetes mellitus combined with microalbuminuria patients using ultrasound radio-frequency

作　　者：张军[1] 齐夏[2] 张恩琴 周艳华[4] 

机构地区：[1]天津市和平区中医医院超声科,300050 [2]天津市南开区王顶堤医院内科,300191 [3]天津市南开区王顶堤医院检验科,300191 [4]天津市南开区王顶堤医院超声科,300191

出　　处：《国际生物医学工程杂志》2017年第1期28-32,I0005,共6页International Journal of Biomedical Engineering

摘　　要：目的 应用超声射频信号技术评价2型糖尿病（T2DM）合并微量白蛋白尿（MA）患者股动脉弹性功能早期改变及临床意义.方法 收集51例T2DM未合并MA患者（A组）和53例T2DM合并MA患者（B组）.为观察受检者股动脉管壁早期弹性变化,二维超声剔除股动脉内-中膜厚度（IMT）〉1.0 mm者.二维超声清晰显示股动脉后,实时启动内-中膜厚度定量分析（QIMT）及动脉僵硬度定量分析（QAS）系统,检测受检者IMT、内径（D）及弹性参数,包括管壁扩张系数（DC）、顺应系数（CC）、弹性系数（α、β）及脉搏波传导速度（PWV）;分析两组间上述参数差异及相关性.同期获得A、B两组患者血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、血肌酐（CREA）、糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2h血糖（2 h PG）及体质量指数（BMI）.结果 同组内男性与女性间及左、右两侧股动脉各弹性参数比较,差异均无统计学意义（均P〉0.05）.B组CC、DC较A组降低,而α、β、PWV均高于A组,其差异均有统计学意义（均P〈0.05）.Pearson相关性分析结果表明,B组CC与α、β、PWV均呈负相关（r=-0.305、-0.312、-0.412,均P〈0.05）;DC与α、β、PWV亦均呈负相关（r=-0.319、-0.324、-0.405,均P〈0.05）.两组间股动脉D比较,差异无统计学意义（P〉0.05）.B组TG、HbA1c、FPG、2hPG均高于A组,差异均有统计学意义（P〈0.05）;而两组间TC、HDL-C、LDL-C、CREA、BMI、年龄差异均无统计学意义（均P〉0.05）.结论 动脉弹性功能减退早于形态学改变,T2DM合并MA时股动脉弹性功能已减退,应用超声射频分析技术对其临床早期诊疗具有一定意义.Objective To evaluate early changes of femoral artery elasticity in type 2 diabetes mellitus （T2DM） combined with microalbuminuria （MA） patients using ultrasound radio-frequency technology,and to study the clinical significance.Methods 51 T2DM without MA patients were enrolled in Group A,and 53 T2DM with MA patients were enrolled in Group B.In order to observe the early elastic changes in the subjects,two-dimensional ultrasound was used to eliminate patients whose intima-media thickness （IMT） was 〉1 mm.The femoral arteries were imaged by two-dimensional ultrasonography,and then the IMT,femoral artery inner diameter （D）,distensibility coefficient （DC）,compliance coefficient （CC）,elasticity coefficient （α and β）,and pulse wave velocity （PWV） were real-time tested using quality intima-media thickness （QIMT） and quality arterial stiffness （QAS） analyzing systems.Besides,the differences and correlation analyses of these parameters between the two groups were conducted.In addition,some other parameters of sujects in both group A and B were also determined and analysed,including total cholesterol （TC）,triglyceride （TG）,low-density lipoprotein cholesterol （LDL-C）,high-density lipoprotein cholesterol （HDL-C）,creatinine （CREA）,glycosylated hemoglobin （HbA1c）,fasting blood glucose （FPG）,2h postprandial plasma glucose （2hPG） and body mass index （BMI）.Results There were no significant differences in the elastic parameters of femoral arteries between the male and female subjects （P〉0.05）,and between left and right sides （P〉0.05） within a same group.Compared with group A,group B had lower CC and DC （P〈0.05） and higher α,β and PWV （P〈0.05）.Pearsons correlation analysis indicateal that,CC was negatively correlated with α,β and PWV （P〈0.05）,and DC was also negatively correlated with α,β and PWV （P〈0.05）.There was no significant difference in the inner diameters of femoral arteries between the two groups （P〉

关 键 词：超声检查 2型糖尿病 微量白蛋白尿 股动脉 

分 类 号：R445.1[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学]