Tenascin-C与糖尿病肾病关系的研究进展  

Research Progress in Correlation between Tenascin-C and Diabetic Kidney Disease

作　　者：周阳[1] 王秋月[1] ZHOU Yang WANG Qiuyue.(Department of Endocrinology and Metabolism, the First Affiliated Hospital, China Medical University, Shenyang 110001, China)

机构地区：[1]中国医科大学附属第一医院内分泌与代谢病科,沈阳110001

出　　处：《医学综述》2017年第8期1608-1612,共5页Medical Recapitulate

摘　　要：糖尿病肾病(DKD)已成为危害人类健康的重要原因,多种途径导致DKD的发生。腱生蛋白C(TNC)作为细胞外基质糖蛋白,不仅存在于多种炎症反应的结果中,还可通过与转化生长因子(TGF)、Toll样受体4(TLR4)、血小板源性生长因子(PDGF)、Wnt/β-联蛋白(β-catenin)等促炎因子的相互作用共同参与炎症反应的发生、发展,但其在DKD中的具体机制尚不清楚。因此,深入探究其机制将为明确DKD的发病提供新的理论依据,同时也可为找到靶向治疗药物提供新的方向。Nowadays, studies found that diabetic kidney disease （DKD） has become a major threat to human health, as many ways may result in DKD. Tenascin-C （TNC）, which is popular recently as an extracellular matrix glyeoprotein, is associated with multiple inflammations. TNC can promote DKD by different pathways through transforming growth factor （ TGF）, Toll-like receptors （TLR） 4, platelet derived growth factor （ PDGF ） -BB, Wnt/β-catenin, although the exact mechanism is still not clear in DKD. Therefore, deeper exploration of the mechanisms can provide new theoretical references for the DKD onset, and point out a new direction for finding the targeted therapeutic medication.

关 键 词：腱生蛋白C 转化生长因子 TOLL样受体4 血小板源性生长因子 Wnt/β联蛋白 

分 类 号：R587.1[医药卫生—内分泌]