虎杖苷对百草枯中毒大鼠急性肺损伤的保护作用  

Protective effects of polydatin on paraquat-induced acute lung injury in rats

作　　者：黄杨[1] 张新彧 孙纪元[1] 刘健[1] 张玲琴[1] 鲁传豪[1] 熊健[1] 尹文[1] HUANG Yang ZHANG Xinyu SUN Jiyuan LIU Jian ZHANG Linqin LU Chuanhao XIONG Jian YIN Wen(Department of Emergency, Xijing Hospital, Fourth Military Medical University, Xi＇an 710032, China)

机构地区：[1]第四军医大学西京医院急诊科,西安710032

出　　处：《临床急诊杂志》2017年第3期182-184,共3页Journal of Clinical Emergency

基　　金：陕西省自然科学基础研究计划项目(No:2016JM8144)

摘　　要：目的:通过虎杖苷(PD)的干预,观察其对百草枯(PQ)中毒急性肺损伤的保护效果。方法:48只大鼠随机分4组:PQ组、PD治疗组、PD对照组和正常对照组。将PD溶液通过尾静脉注入大鼠体内,观察末次注射后第3、7天各组大鼠的肺干湿比、血浆中IL-1β、TNF-α、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-PX)的水平变化。结果:与PQ组相比,在末次注射后的第3、7天PD治疗组明显降低肺干湿比(P<0.01)和炎性递质IL-1β、TNF-α的含量(P<0.01),降低血浆中MDA的水平(P<0.01)和升高SOD、GSH-PX的水平(P<0.01)。PD对照组在各时段与正常对照组比较差异无统计学意义。结论:PD对PQ中毒急性肺损伤具有保护作用。Objective：To investigate the protective effects of polydatin on paraquat-induced acute lung injury in rats. Method：Forty-eight female SD rats were divided randomly into five groups： PQ group, PD treatment group, PD control group and normal control group. The lung wet/dry weight ratios of the rats were calculated at 3 and 7 days after last injections in each group. At the same time,the levels of Interleukin-1β （IL-1β）,tumor necrosis factor-α （TNF-α）,malondialdehyde （MDA）,superoxide dismutase （SOD）,glutathione peroxidase （GSH-PX） in plas- ma were detected. Result：In PD treatment group, the ratio of lung wet/dry weight （P〈0.01）, plasma IL-1β and TNF-α levels （P〈0.01）, MDA levels （P〈0.01） were significantly lower than those at 3 and 7 days after last in- jections in the PQ group. However,the SOD and GSH-PX levels began to increase （P〈0.01） compared with the PQ group. There was no significant difference between the PD control group and the normal control group. Conclusion：PD have protective effects on paraquat-induced acute lung injury in rats.

关 键 词：虎杖苷 百草枯 急性肺损伤 中毒 

分 类 号：R563[医药卫生—呼吸系统]