化痰除湿祛瘀法结合手术治疗膝关节骨性关节炎  

Treatment of knee osteoarthritis with the method oiHuatan Chushi Quyu and surgery

作　　者：马奇翰 梁国强 尢君怡[1] 孟祥奇[1] 

机构地区：[1]苏州市中医医院骨伤科,江苏苏州215003 [2]苏州吴门医派研究院,江苏苏州215003

出　　处：《长春中医药大学学报》2017年第2期285-288,共4页Journal of Changchun University of Chinese Medicine

基　　金：江苏省苏州市科技局科研立项"化痰除湿祛瘀剂对膝骨关节炎患者的软骨凋亡调控基因Bc-2;Bax及p53mRNA表达的影响"(SYS201420)

摘　　要：目的观察化痰除湿祛瘀法结合手术治疗膝关节骨性关节炎的临床疗效。方法将103例膝关节骨关节炎患者随机分为2组,对照组52例,采用关节镜治疗或膝关节置换治疗;观察组51例,采用化痰除湿祛瘀剂+关节镜治疗或膝关节置换治疗,8周为1个疗程,对比观察Womac骨关节炎指数评分、Lequesne评分以及血液IL-1、TNF-α的含量。结果观察组显效率为64.71%,显著高于对照组的40.38%;治疗后观察组Womac骨关节炎指数评分、Lequesne评分显著优于对照组(P<0.05);治疗后血液中IL-1含量均显著降低(P<0.05)。结论化痰除湿祛瘀法结合手术治疗膝关节骨性关节炎能显著改善临床症状,降低血液IL-1的含量。Objective To observe the clinical effects of Huatan Chushi Quyu preparation and surgery in treating knee osteoarthritis. Methods 103 knee osteoarthritis patients were randomly divided into two groups：control group （n=52） was treated with arthroscopic treatment or knee replacement therapy.The test group （n=51） was treated with Huatan Chushi Quyu preparation and arthroscopic treatment or knee replacement therapy. Both for 8 weeks. A comparative analysis was carried out with respect to Womac index, Lequesne scale, as well as the levels of IL-1, TNF-a in blood. Results The effective percentage in the test group （64.71%） was significantly higher than the control group（40.38%）.After treatment, Womac index and Lequesne scale in blood are Significantly better than the control group （P〈0.05）; The levels of IL-1 in blood were significantly reduced after the treatment（P〈0.05）. ConeIusion Therapeutic method ofHuatan Chushi Quyu preparation and surgery

关 键 词：膝关节骨性关节炎 化痰除湿祛瘀:IL-1 TNF-Α 

分 类 号：R274.9[医药卫生—中西医结合]