新生儿胎粪中邻苯二甲酸酯代谢物与脐带血激素水平的关联  

Phthalate metabolites in meconium and their associations with hormones in cord blood

作　　者：郭佳林[1] 高曦[2] 陈婧司 刘颖钏 孙静[1] 贲晓明[1] 吴岷[2] 厉曙光 陈波[2] 

机构地区：[1]同济大学附属第一妇婴保健院新生儿科,上海201204 [2]复旦大学公共卫生学院营养与食品卫生教研室,教育部公共卫生安全重点实验室,上海200032

出　　处：《环境与职业医学》2017年第4期291-296,共6页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(编号:81202208,81172673);国家重点研发计划(编号:2016YFD0400602)

摘　　要：[目的]了解新生儿邻苯二甲酸酯(PAEs)宫内暴露的质量浓度(后称"浓度"),并探索其与新生儿性激素或甲状腺激素水平的关联。[方法]收集新生儿胎粪并检测胎粪中常见PAEs的代谢物,收集脐带血并检测游离睾酮(FT)、总四碘甲状腺素(T4)等常见性激素指标和甲状腺激素指标,并采用线性回归方法分析两者间的关系。[结果]新生儿胎粪中检出的代谢物主要是邻苯二甲酸单乙基己酯(MEHP)、邻苯二甲酸单正丁酯(Mn BP)和邻苯二甲酸单异丁酯(Mi BP),检出率分别为100%、99%和99%。男性新生儿雌二醇(E2)水平与邻苯二甲酸单甲酯(MMP)(b=2.44,P=0.027)、Mn BP(b=4.08,P=0.044)及Mi BP(b=3.89,P=0.003)呈正相关,FT与MEHP(b=4.42,P=0.049)呈正相关;女性新生儿性激素水平与各PAEs代谢物浓度未见关联。除男性促甲状腺激素(TSH)与邻苯二甲酸单乙酯(MEP)浓度(b=0.40,P=0.015)呈正相关外,新生儿甲状腺激素其余指标与PAEs浓度均未见关联。[结论]新生儿宫内暴露于PAEs与新生儿的性激素水平变化可能存在一定的关联。[ Objective ] To understand the fetal exposure concentrations to phthalic acid esters （PAEs） and assess the associations between PAEs concentrations and the levels of sex hormones or thyroid hormones in newborns. [ Methods ] Linear regression models were used to assess the associations between PAEs metabolites in meconium samples and sex or thyroid hormones [free testosterone （FT） and total thyroxine （T4）] in cord blood samples. [ Results ] The main metabolites in meconium were mono-2-ethylhexyl phthalate （MEHP）, mono-n-butyl phthalate （MnBP）, and monoisobutyl phthalate （MiBP）, with detection rates of 100%, 99%, and 99%, respectively. Estradiol level in newborn boys was positively correlated to the concentrations monomethyl phthalate （MMP） （b=2.44, P=0.027）, MnBP （b=4.08, P=0.044）, and MiBP （b=3.89, P=0.003）. FT in newborn boys was positively correlated to MEHP （b=4.42, P=0.049）. None of PAEs metabolite concentrations was related to sex hormone level in newborn girls. Thyroid stimulating hormone （TSH） level in newborn boys was positively correlated to MEP concentration （b=0.40, P=0.015）. No other associations between thyroid hormone levels and PAEs metabolite concentrations in meconium were found.[ Conclusion ] Fetal exposure to PAEs may be associated with changes of sex hormone levels in newborns.

关 键 词：邻苯二甲酸酯类 胎粪 脐带血 性激素 甲状腺激素 

分 类 号：R12[医药卫生—环境卫生学] R17[医药卫生—公共卫生与预防医学]