Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups  

作　　者：LI Xing LI Ning SUN Hua Lei YIN Jun TAO Yu Chang MAO Zhen Xing YU Zeng Li LI Wen Jie John D BOGDEN 

机构地区：[1]College of Public Health,Zhengzhou University [2]College of Food Science and Technology,Henan Agriculture University [3]Department of Microbiology,Biochemistry,and Molecular Genetics,Rutgers New Jersey Medical School

出　　处：《Biomedical and Environmental Sciences》2017年第3期215-219,共5页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC),No.31201878,81172716,and U1204804;Post Doctoral Foundation of China,No.2015M572109;Post Doctoral Fund of Henan province,No.2014049

摘　　要：Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease （AD）. Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.Lead exposure is a known potential risk factor for neurodegenerative diseases such as Alzheimer’s disease （AD）. Exposure to lead during the critical phase of brain development has been linked with mental retardation and hypophrenia in later life.

关 键 词：AD Maternal Lead Exposure Induces Down-regulation of Hippocampal Insulin-degrading Enzyme and Nerve Growth Factor Expression in Mouse Pups IDE NGF 

分 类 号：R114[医药卫生—卫生毒理学]