桂枝茯苓丸辅助氨甲蝶呤及米非司酮治疗输卵管间质部妊娠的临床观察  

Treatment of interstitial tubal pregnancy with Guizhi Fuling pill assisted with methotrexate and mifepristone

作　　者：郭敏慧[1] 赖筱琍[1] 王丹[1] 

机构地区：[1]浙江省台州医院妇产科

出　　处：《中国生化药物杂志》2017年第4期177-179,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 观察桂枝茯苓丸辅助氨甲蝶呤及米非司酮治疗输卵管间质部妊娠的临床疗效。方法 2015年1月~2016年6月浙江省台州医院收治的90例输卵管间质部妊娠患者,根据入院顺序编号和奇偶数进行分组,对照组和观察组各45例。对照组接受氨甲蝶呤及米非司酮治疗,观察组在以上两种药物治疗基础上加用中药桂枝茯苓丸。分析并对比2组患者治疗成功率、血β-人绒毛膜促性腺激素（β-HCG）值转阴时间、包块消失时间、住院时间以及期间发生的不良反应。结果 （1）治疗后,观察组治疗成功率为91.11%,且治疗成功的患者中有80.49%输卵管畅通;对照组治疗成功率为88.89%,输卵管畅通率为77.50%,观察组均略高于对照组,但差异均不具有统计学意义。（在治疗成功的2组患者中,观察组血β-HCG值转阴时间、包块消失时间和住院时间分别为（13.05±1.08、24.09±1.43、15.37±0.82）天,均短于对照组（17.39±1.50、27.43±2.19、18.85±1.）天（P〈0.05）。（3）观察组治疗期间不良反应的总比例为11.11%,低于对照组26.67%,且差异有统计学意义（P〈0.05）。结论 桂枝茯苓丸辅助氨甲蝶呤及米非司酮能缩短间质部妊娠患者治疗时间,并减少不良反应。Objective To analyze treatment of tubal interstitial pregnancy with Guizhi Fuling pill assisted with methotrexate and mifepristone. Methods 90 cases tubal interstitial pregnancy patients from January 2015 to June 2016 were grouped by admission order and each group with 45 ases. Methotrexate and mifepristone therapy were given the control group, Guizhi Fuling pill assisted with methotrexate and mifepristone were given the bservation group. Treatment success rate, ｜3-HCG negative time,mass disappearance time,length of hospitalization and adverse reactions were compared. Results （After treatment, treatment success rate of observation group was 91. 11% and 80. 49% of tubal smooth,witch all higher than control group with （88. 89% ,77. 50% ） ,but the difference was not statistically significant. （For the treatment of two groups of patients with success, j3-HCG negative me,mass disappearance time and length of hospitalization of observation group were （ 13. 05 ± 1. 08, 24. 09 ± 1. 4 3, 15. 37 ± 0. 82 ） days, shorter than ontrol group with （ 17. 39 ± 1. 50, 27. 43 ± 2. 1 9, 18. 85 ± 1. ） days （ P 〈 0. 05 ）.③ During treatment,adverse reactions of observation group was 1. 11% , lower than control group with 26. 67% （P 〈0. 05）. Conclusion Guizhi Fuling pill assisted with methotrexate and mifepristone can shorten eatment time and reduce side effects for tubal interstitial pregnancy patients.

关 键 词：桂枝茯苓丸 氨甲蝶呤 米非司酮 输卵管间质部妊娠 

分 类 号：R714.22[医药卫生—妇产科学]