左氧氟沙星治疗社区获得性肺炎的临床评价及对血清C反应蛋白及白细胞的影响  

Effects of levofloxacin on serum CRP and WBC in community-acquiredpneumonia

作　　者：郎明霞[1] 戚建巨 

机构地区：[1]宁波大学医学院附属医院内科,浙江宁波315020 [2]宁波大学医学院附属医院急诊内科,浙江宁波315020

出　　处：《中国生化药物杂志》2017年第4期235-237,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨左氧氟沙星治疗社区获得性肺炎,对患者血清C反应蛋白（CRP）及白细胞（WBC）的影响,并分析临床疗效。方法 选择2010年1月~2013年12月于宁波大学医学院附属医院就诊的60例社区获得性肺炎患者,按抽签法分为对照组（n=30）及研究组（n=30）,对照组采用阿莫西林克拉维酸钾联合阿奇霉素治疗,研究组采用左氧氟沙星单药治疗,比较2组临床效果,临床表现消失时间,CRP、WBC,免疫功能和安全性。结果 2组有效率比较差异无统计学意义。研究组发热、咳嗽及肺部湿啰音消失分别为（3.23±0.48）d、（7.84±1.12）d、（8.26±1.18）d,时间少于对照组（4.69±0.66）d、（9.30±1.34）d、（9.87±1.43）d,差异有统计学意义（P〈0.05）。治疗后,研究组CRP、WBC分别为（29.54±4.15）mg/L、（7.11±1.10）×109/L,低于对照组（36.41±5.17）mg/L、（8.25±1.15）×109/L,差异有统计学意义（P〈0.05）。研究组免疫功能改善较对照组更明显,差异有统计学意义（P〈0.05）。2组安全性比较差异无统计学意义。结论 左氧氟沙星治疗社区获得性肺炎效果更好。Objective To investigate the effects of levofloxacin in the treatment of community-acquired pneumonia and the influence on serum levels of c-reactive protein （CRP） and white blood cell （WBC）. Methods 6 0 patients w i t h c o m m u n i t y a c q u i r e d p n e u m o n i a f r o m J a n u a r y 2 0 1 0 to December 2013 in Affiliated Hospital of Ningbo University Medical College were selected and divided into control group （n, =30） and research group （ n = 30） , the control group was treated with amoxicillin potassium clavulanate joint azithromycin, the research group was treated with levofloxacin, the clinical effect, clinical symptoms disappear time, CRP, WBC, immune function and safety of two groups were compared. Results T h e r e w a s n o significant difference in the efficiency of the two groups. The fever, cough and lung wet rale disappearing time of research group was （3. 23 ± 0. 48 ） d, （7. 84 ± 1. 12） d, （8. 26 ± 1. 18） d, less than the control group （4. 69 ±0. 66） d, （9. 30 ± 1. 34） d, （9. 87 ± 1. 43） d, the difference was statistically significant （P 〈0. 05）. After treatment, the CRP, WBC of research group was （29. 54 ±4. 15） mg/L, （7. 11 ± 1. 10） X 109/L, lower than the control group （36. 41 ± 5. 17） mg/L, （8. 25 ± 1. 15 ） X 109/L, the difference was statistically significant （ f＊ 〈 0. 05 ） . The immune function of research group was improved more significantly than control group, the difference was statistically significant （P 〈 0. 05 ）. There was no significant difference in safety between the two groups. Conclusion The effect is reliable of l e v o f loxacin t r eatment of community-acquired pneumonia, and can decrease the serum level of CRP and WBC.

关 键 词：社区获得性肺炎 左氧氟沙星 临床效果 C反应蛋白 白细胞 

分 类 号：R563.1[医药卫生—呼吸系统]