莫西沙星与左氧氟沙星治疗尿路感染对治愈率、不良反应发生率的影响  

Effect of moxifloxacin and levofloxacin on the cure rate of urinary tract infection and the incidence of adverse reactions

作　　者：邵佳[1] 

机构地区：[1]杭州市肿瘤医院泌尿外科

出　　处：《中国生化药物杂志》2017年第4期241-242,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 探讨莫西沙星与左氧氟沙星治疗尿路感染对治愈率、不良反应发生率的影响。方法 选取2015年1月~2016年9月于杭州市肿瘤医院就诊的尿路感染患者92例,采用随机数字表法,分为A组与B组,每组各46例。A组患者给予莫西沙星治疗,B组患者给予左氧氟沙星治疗,对比2组患者的治疗效果。结果 A组患者的临床总有效率、临床治愈率显著高于B组,差异有统计学意义（P〈0.05）;2组患者的不良反应发生率、细菌清除率比较差异无统计学意义。A组患者不良反应发生率为10.87%,药物治疗成本为275.47元,成本-疗效比3.17;B组患者不良反应发生率为13.04%,药物治疗成本为45.50元,成本-疗效比0.59,2组患者的不良反应发生率比较差异无统计学意义;A组患者的药物成本、成本-效果比显著优于B组,差异有统计学意义（P〈0.05）。结论莫西沙星治疗尿路感染的临床效果更显著,但左氧氟沙星治疗的药物成本更低。Objective To investigate the effect of moxifloxacin and levofloxacin on the treatment of urinary tract infection and the incidence of adverse reactions. Methods 92 cases of patients with urinary tract infection from January 2015 to September 2016 in Hangzhou cancer hospital were selected and randomly divided into group A and group B with 46 cases in each group. Group A were treated with moxifloxacin treatment, group B were treated with levofloxacin in the treatment, compared with the treatment of two groups of patients. Results T h e clinical effective rate a n d clinical c u r e rate of group A were significantly higher than those of group B, the difference was statistically significant （ P 〈 0. 05 ） , there was no significant difference in the incidence of adverse reactions and bacterial clearance between the two groups. The incidence of adverse reactions in group A was 10. 87% , drug cost was 275. 47 yuan, the cost effectiveness ratio of 3. 17 , the incidence of adverse reactions in group B was 13. 04% , drug cost was 45. 50 yuan, cost- effectiveness ratio of 0. 59, there was no significant difference in the incidence of adverse reactions between the two groups; the cost of d r u g a n d cost- effectiveness of group A was significantly better than group B, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Moxifloxacin is m o r e effective in the treatment of urinary tract infections, but levofloxacin has lower drug costs.

关 键 词：莫西沙星 左氧氟沙星 尿路感染 不良反应 

分 类 号：R691.3[医药卫生—泌尿科学]