匹多莫德对支原体肺炎患儿免疫及炎性因子的影响  

Effect of Pidotimod on Immune and Inflammatory Factors of Children with Mycoplasma Pneumonia

作　　者：陈彦伶[1] 吴善姬[2] 

机构地区：[1]吉林医药学院附属医院儿科,吉林吉林132023 [2]吉林省吉林市人民医院儿科,吉林吉林132001

出　　处：《河北医学》2017年第3期377-380,共4页Hebei Medicine

基　　金：辽宁省2015年自然科学基金计划立项项目;(编号:2015020552)

摘　　要：目的:观察匹多莫德对支原体肺炎患儿免疫及炎性因子的影响。方法:选取2013年3月至2015年7月在我院进行诊治的80例支原体肺炎患儿根据随机分层分组法分为对照组和观察组各40例,其中对照组患儿应用阿奇霉素治疗,观察组患儿则在对照组治疗基础上联合应用匹多莫德,对比分析两组患儿治疗后免疫功能指标(CD3+、CD4+、CD8+、CD4+/CD8+)及炎性因子(IL-10、IL-6、TNF-α)水平化情况。结果:治疗后两组患儿IL-10、IL-6、TNF-α水平比较观察组均低于对照组(t=5.731,P<0.05),治疗后两组患儿CD3+、CD4+、CD4+/CD8+水平比较观察组均高于对照组(t=5.538,P<0.05),CD8+则较对照组降低(t=5.652,P<0.05),差异有统计学意义。结论:临床应用匹多莫德治疗支原体肺炎可改善患儿机体炎性状态及免疫功能。Objective： To observe the effect of pidotimod on immune and inflammatory factors of children with mycoplasma pneumonia.Methods： 80 cases of children with mycoplasma pneumonia treated in our hospital from March 2013 to July 2015 were selected and divided into control group and observation group according to random stratified grouping method,40 cases in each group. The control group was given Azithromycin for treatment,while the observation group was given pidotimod on the basis of the treatment in the control group,then the level changes of immune function and inflammatory factors in the two groups were compared.Results： After treatment,immune function detecting indexes（ IL-10,IL-6,TNF-α） in the observation group were all lower than those in the control group（ t = 5.731,P 〈0.05,inflammatory factor（ CD3 ＋,CD4 ＋,CD8 ＋,CD4＋/CD8＋） level in the observation group were all higher than those in the control group（ t = 5. 538,P 〈 0.05）,CD8＋ level in the observation group was lower than that in the control group（ t = 5.652,P 〈0.05）. Conclusion： Clinical application of pidotimod for the treatment on children with mycoplasma pneumonia can improve the body’s inflammatory status and immune function.

关 键 词：匹多莫德 支原体肺炎 免疫功能 炎性因子 

分 类 号：R725.6[医药卫生—儿科]