全麻老年患者术后静注氟马西尼影响认知功能和S100β蛋白的表达研究  

Elderly Patients with General Anesthesia Postoperative Static Note Fluorine Marcie's Influence Cognitive Function and According to Research of Beta Protein Expression

作　　者：王婷[1] 叶力肯.叶尔道来提 米日古丽[1] 王龙[1] 

机构地区：[1]新疆医科大学第二附属医院麻醉科,新疆乌鲁木齐830028

出　　处：《河北医学》2017年第3期408-411,共4页Hebei Medicine

基　　金：新疆维吾尔自治区自然科学基金;(编号:2014211C085)

摘　　要：目的:研究全麻老年患者术后静注氟马西尼影响认知功能和S100β蛋白的表达情况。方法:选取2015年4月至2016年3月,在我院接受骨科手术治疗的老年患者82例。根据随机原则分为观察组及对照组各41例。所有患者均进行全麻处理,随后对照组给予5m L生理盐水静脉注射,观察组则给予氟马西尼5m L静脉注射。分别比较两组患者手术时间术中出血量、苏醒时间、拔管时间,手术前后MMSE评分、血清S100β蛋白水平以及注射前后OAA/S评分。结果:观察组苏醒时间、拔管时间分别为(8.7±3.1)min、(13.1±2.4)min,均低于对照组的(12.9±2.9)min、(15.8±3.7)min,差异均有统计学意义(均P<0.001)。术后6h、术后1d、术后3d观察组MMSE评分均高于对照组,差异均有统计学意义(均P<0.001)。术后6h、术后1d观察组血清S100β水平均低于对照组,差异有统计学意义(P<0.05)。注射后1min、2min、5min观察组患者的OAA/S评分均高于对照组,差异有统计学意义(P<0.05)。结论:全麻老年患者术后静注氟马西尼可有效缩短患者术后苏醒时间、拔管时间,同时提高患者MMES评分、降低S100β蛋白浓度,有利于降低患者术后认知功能障碍的发生。Objective： To study the anesthesia in elderly patients with postoperative static note fluorine marcie’s influence cognitive function and according to beta protein expression. Methods： Chose between April2015 and March 2016,orthopaedic surgery treated in our hospital 82 cases of elderly patients. According to random number table method was divided into observation group and the control group each had 41 cases. All patients with general anesthesia processing,then the control group was given 5 ml saline intravenous injection,the observation group were given fluorine marcie,5 ml intravenous injection. Respectively compared two groups of patients bleeding amount of operating time,wake up of time,extubation time,MMSE score,serum according to beta protein levels before and after operation and the OAA/S score before and after injection. Results： The observation group of waking time,extubation time,respectively（ 8.7±3.1） min and（ 13.1±2.4）min,were significantly lower than in the control group（ 12. 9 ± 2. 9） min and（ 15. 8 ± 3. 7） min,differences were statistically significant（ all P 〈 0.001）. After 6 h,1 d after operation,postoperative MMSE score 3 d observation group were significantly higher than that of control group,differences were statistically significant（ all P 〈 0.001）. 6 h after surgery,postoperative serum according to beta level 1 d observation group were significantly lower than the control group,the difference had statistical significance（ P 〈 0.05）. 1 min,2 min,5 min after injection of OAA/S score of observation group patients were significantly higher than the control group,the differences were statistically significant（ all P 〈 0.05）. Conclusion： General anesthesia in elderly patients with postoperative static note fluorine marcie,which can effectively shorten the postoperative patients with waking time,extubation time,at the same time improve patients MMES score,reduce according to beta protein concentration,reducing the occurrence of postoperative cog

关 键 词：氟马西尼 认知功能 S100Β蛋白 

分 类 号：R614.2[医药卫生—麻醉学]