美托洛尔联合乌司他丁治疗COPD并心力衰竭的临床研究  

Clinical study of metoprolol combined with ulinastatin in the treatment of COPD complicated with heart failure

作　　者：曹臣龙[1] 张样杰 翟成凯[1] 

机构地区：[1]河南省新乡市第一人民医院呼吸科一病区,453000

出　　处：《中国实用医刊》2017年第6期24-26,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察关托洛尔联合乌司他丁治疗慢性阻塞性肺疾病（COPD）并心力衰竭的临床疗效。方法将2010年6月至2012年6月94例COPD合并心力衰竭患者随机分为观察组和对照组，对照组给予乌司他丁治疗，观察组在对照组基础上联用关托洛尔治疗。比较两组患者心脏功能改善、第1秒用力呼气客积（FEV1）、第1秒用力呼气容积／用力肺活量（FEV1／FVC）、心率、血氧饱和度、血压和生活质量评分。同时比较两组患者不良反应。结果观察组患者心功能改善及FEVI、FVC和FEV1／FVC等指标明显高于对照组，同时观察组心率、血压及呼吸症状、活动能力、疾病影响和SGRQ评分均明显低于对照组，差异均有统计学意义（P〈0．05）。两组患者不良发生发生率均较低，差异未见统计学意义（P〉0．05）。结论乌司他丁联合美托洛尔治疗COPD合并心力衰竭，能有效改善COPD患者的心肺功能，提高患者生活质量，值得临床推广使用。Objective To observe the clinical effect of metoprolol combined with ulinastatin on chronic obstructive pulmonary disease （COPD） complicated with heart failure. Methods Ninety-four patients with COPD complicated with heart failure from June 2010 to June 2012 were randomized divided into observation group and control group. The control group was treated with ulinastatin, while the observation group was treated with metoprolol on the basis of the control group. The improvement of cardiac function, forced expiratory volume in the first second （ FEV1 ）, forced expiratory volume in the first second / forced vital capacity （ FEV1/FVC）, heart rate, blood oxygen saturation, blood pressure, quality of life scores and adverse reactions between the two groups were compared. Results The improvement of cardiac function, FEV1, FVC and FEV1/FVC in observation group were significantly higher than those in control group, while the heart rate, blood pressure, SI, MA, DA and SGRQ score were significantly lower （ P 〈 0. 05）. The incidence rates of adverse reactions were lower in both groups （ P 〉 0.05 ）. Conclusions The application of ulinastatin combined with metoprolol in treatment of COPD with HF can effectively improve the heart function and lung function, and improve the quality of life of patients.

关 键 词：关托洛尔 乌司他丁 慢性阻塞性肺疾病 心力衰竭 

分 类 号：R563.8[医药卫生—呼吸系统] R563.9[医药卫生—内科学]