短期应用复方左旋肉碱在单精子卵胞浆注射治疗男性不育中的作用  

Short term application of compound L-carnitine in the treatment of male infertility by intracytoplasmic sperm injection

作　　者：高国政[1] 常轲祎 王芳[1] 

机构地区：[1]郑州大学附属洛阳中心医院生殖中心,河南洛阳471009

出　　处：《中国实用医刊》2017年第6期68-70,共3页Chinese Journal of Practical Medicine

摘　　要：目的观察复方左旋肉碱短期治疗男性严重少弱精子症后精液质量的变化及行单精子卵胞浆注射助孕治疗后的结局。方法根据WH04标准检测精液分析结果为严重少弱精子症者75例，治疗组32例服用复方左旋肉碱2周后应用ICSI，对照组43例单纯应用ICSI助孕技术。比较治疗组患者用药前后精子密度、a＋b级精子百分率、精子畸形率、精于DNA碎片率指标，比较两组ICSI后受精率、卵裂率、有效胚胎率、临床妊娠率。结果治疗组患者治疗后前向运动精子百分率较治疗前提高，畸形率和精子DNA碎片降低，治疗组ICSI操作后有效胚胎率为77．5％，明显高于对照组的69．04％（P〈0．05）。结论短期应用复方左旋肉碱能够改善严重少弱精子症患者的精子质量，并有助于提高严重少弱精子症患者ICSI的成功率。Objective To observe the changes of semen quality and the outcome of intracytoplasmic sperm injection after short term treatment with compound L-carnitine in the male patients with severe oligospermia and asthenospermia. Methods According to the standard of WHO4 semen analysis, this study included 75 patients with severe oligospermia and asthenospermia. Thirty-two cases in the treatment group were treated with compound L-carnitine for 2 weeks before the ICSI, 43 cases in control group were not treated before the ICSI. The sperm concentration, the percentage of a ＋ b sperm, sperm deformity rate, sperm DNA fragmentation rate were compared before and after treatment. The fertility rate, cleavage rate, effective embryo rate and clinical pregnancy rate of the two groups were analyzed after the ICSI. Results In the treatment group, the percentage of forward moving sperm was higher after treatment, and the abnormal rate, sperm DNA fragmentation rate were lower. The effective embryo rate of the treatment group （ 77.5% ） was significantly higher than that of the control group （69.04%, P 〈 0. 05 ）. Conclusions Short term application of compound L-carnitine can improve sperm quality in patients with severe oligospermia and asthenospermia, and help to improve the success rate of ICSI in patients with severe oligospermia and asthenospermia.

关 键 词：复方左旋肉碱 单精子卵胞浆注射 不育 

分 类 号：R698.2[医药卫生—泌尿科学]