亚砷酸联合沙利度胺治疗骨髓增生异常综合征疗效观察  

Effect Observation of Thalidomide Combined with Arsenious Acid in the Treatment of Myelodysplastic Syndrome

作　　者：钟俊武[1] 骆超[1] 赵彩芳[1] 徐晗[1] 

机构地区：[1]金华市中心医院血液科,浙江金华321001

出　　处：《药物流行病学杂志》2017年第4期234-236,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨亚砷酸与沙利度胺联合治疗骨髓增生异常综合征(MDS)的疗效和安全性。方法:MDS患者68例随机分为观察组34例与对照组34例。对照组采用沙利度胺治疗,观察组在对照组基础上加用亚砷酸治疗。两组均以6周为1个疗程,连续治疗4个疗程。比较两组疗效和药品不良反应发生情况;观察两组患者治疗2个和4个疗程时的骨髓象变化以及治疗前后患者血象变化。结果:观察组总有效率高于对照组(P<0.05)。观察组治疗2个疗程和4个疗程时,原始细胞比例减少的发生率均高于对照组(P<0.05);且两组治疗4个疗程原始细胞比例减少的发生率均高于治疗2个疗程(P<0.05)。治疗后,两组患者WBC、Hb、Plt等指标较治疗前均有明显增加(P<0.05),且观察组各项指标均高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:亚砷酸与沙利度胺联合治疗骨髓增生异常综合征的疗效肯定,且安全性好。Objective ：To study the effect and safety of arsenious acid combined with thalidomide in the treatment of myelodysplastic syndrome （MDS）. Methods：68 patients with MDS were randomly divided into observation group and control group, each 34 cases. The control group were treated with thalidomide, the observation group were given arsenious acid additionally on the basis of the control group. The patients of two groups were treated for 6 weeks for 1 courses of treat- ment, continuous observation of 4 courses. The curative effect and adverse drug reactions of the two groups were compared, treatment 2 and 4 courses of bone marrow change, and change of hemogram before and after treatment of patients in the two groups were observed. Results： The total effective rate of the observation group was higher than that of the control group （ P 〈 0.05 ）. When treated with 2 courses of treatment and 4 treatment, the original cell proportion of observation group was higher than the control group （P 〈 0.05 ）. While treated 4 courses of treatment, the original cell proportion of two groups were higher than 2 courses of treatment （P 〈 0.05）. After treatment, the WBC, Hb, Plt of two groups increased significantly than before （ P 〈 0.05 ）, and the WBC, Hb, Ph of observation group were higher than the control group （ P 〈 0.05 ）. There was no significant difference in the incidence of adverse drug reactions between the two groups （P 〉 0.05）. Conclusion：Arsenious acid combined with thalidomide in the treatment of MDS had curative effect, it was safe and reliable.

关 键 词：骨髓增生异常综合征 亚砷酸 沙利度胺 疗效 安全性 

分 类 号：R979.1[医药卫生—药品]