曲美他嗪联合左卡尼汀治疗慢性心力衰竭的疗效观察  

作　　者：崇爱国[1] 季红慧[1] 钟泽[1] 吴新东[1] 张伟伟[1] 

机构地区：[1]浙江大学医学院附属第二医院建德分院,311600

出　　处：《浙江临床医学》2017年第5期851-852,共2页Zhejiang Clinical Medical Journal

基　　金：浙江省医学会临床科研基金（2015ZYC-A45）

摘　　要：目的观察曲美他嗪联合左卡尼汀治疗慢性心力衰竭的疗效。方法慢性心力衰竭患者150例，所有患者均接受常规抗心力衰竭药物治疗，在此基础上按随机原则分为联合组1、联合组2及对照组，每组各50例。联合组予曲美他嗪20mg，3次／d，并联用不同剂量左卡尼汀，1次／d，对照组予治疗曲美他嗪20mg，3次／d，14d后观察各组疗效并比较。结果治疗14d后，联合组2患者6分钟步行距离、左室射血分数改善优于其他两组（P〈0．05），而BNP下降幅度在联合组1和联合组2中差异无统计学意义（P〉0．05），但明显高于对照组（P〈0．05）。结论在常规治疗基础上，曲美他嗪联合小剂量的左卡尼汀，可改善心力衰竭患者的心功能。Objective To investigate the efficacy of different dosages of L-carnitine combined with trimetazidine in treating patients with chronic heart failure. Methods 150 patients chronic heart failure were randomly divided into control group （ n=50 ） and different dosages of L-canitine （ i.e., lg, 2g, n=50 in each group ） combined with trimetazidine groups, named combined 1 group, combined 2 group respectively. Patients in the control group received conventional anti-heart failure drugs, those in combined groups received trimetazidine （ 20mg Tid ） and L-canitine intravenously 1g/d, 2g/d, respectively.Efficacy of each group was observed after 14 days. Results After received trimetazidine 20mg Tid and L-canitine 2g/d for 14 days and six-minnte walking distance and left ventricular ejection fraction were significantly improved compared to other groups （ P〈0.05 ） , BNP Level significantly decreased in combined 1 group and combined 2 group compared to control group （ P〈0.05 ） , but there was no significantly difference between the two groups （ P〉0.05 ） . Conclusion Trimetazidine combined with low dose L-canitine can improve heart function.

关 键 词：心力衰竭 心功能 左卡尼汀 曲美他嗪 

分 类 号：R541.61[医药卫生—心血管疾病]