硝苯地平联合硫酸镁对妊娠期高血压患者血液流变学及凝血指标的影响  

Effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension

作　　者：詹前美[1] 陈坤[1] 冯金[1] 陈贤华[1] 

机构地区：[1]广西柳州市柳铁中心医院,广西柳州545007

出　　处：《海南医学院学报》2017年第5期645-647,共3页Journal of Hainan Medical University

基　　金：柳州市科技局基金(2011J0302034)~~

摘　　要：目的:探讨硝苯地平联合硫酸镁对妊娠期高血压综合征(妊高征)患者血流变学指标和凝血指标的影响。方法:选取妊高征患者90例,随机分为对照组与观察组,各45例。观察组给予硫酸镁联合硝苯地平治疗,对照组仅给予硫酸镁治疗,2组均连续治疗2周;检测并比较治疗前后2组血压、血流变学指标及凝血指标变化。结果:治疗后2组SBP、DBP、全血高、中、低切黏度、血浆粘度和红细胞压积相对治疗前显著降低(P<0.05);观察组治疗后上述各指标水平显著低于对照组(P<0.05);2组治疗后PT、APTT及TT较治疗前均有显著升高,Fib较治疗前显著降低(P<0.05),观察组治疗后PT、APTT及TT显著高于对照组,Fib明显低于对照组(P<0.05)。结论:硝苯地平联合硫酸镁可明显稳定妊高征患者血压水平,改善其血流变学及凝血指标,疗效显著。Objective： To explore the effect of nifedipine in combined with magnesium sulfate on the hemorheology and coagulation indicators in patients with gestational hypertension.Methods： A total of 90 patients with gestational hypertension were included in the study and randomized into the observation group and the control group with 45 cases in each group.The patients in the observation group were given magnesium sulfate in combined with nifedipine, while the patients in the control group were only given magnesium sulfate.The patients in the two groups were continuously treated for 2 weeks.The blood pressure, hemorheology indicators, and coagulation indicators before and after treatment in the two groups were detected and compared.Results： SBP, DBP, whole blood high, moderate, and low shear viscosity, plasma viscosity, and HCT after treatment in the two groups were significantly reduced when compared with before treatment （P〈0.05）.The levels of the above indicators after treatment in the observation group were significantly lower than those in the control group （P〈0.05）.PT, APTT, and TT after treatment in the two groups were significantly elevated when compared with before treatment （P〈0.05）, while Fib was significantly reduced （P〈0.05）.PT, APTT, and TT after treatment in the observation group were significantly higher than those in the control group （P〈0.05）, while Fib was significantly lower than that in the control group （P〈0.05）.Conclusions： Nifedipine in combined with magnesium sulfate can significantly stabilize the blood pressure level in patients with gestational hypertension, and improve the hemodynamic and coagulation indicators, with a significant efficacy.

关 键 词：妊娠期高血压综合征 硫酸镁 硝苯地平 血压 血流变 凝血 

分 类 号：R714.24[医药卫生—妇产科学]