血清炎性因子及胰岛素样生长因子相关指标与妊娠期高血压疾病的相关性研究  

Study on the correlation of serum inflammatory cytokine and insulin-like growth factor related indicators with hypertensive disorder complicating pregnancy

作　　者：王斌 白睿[2] 

机构地区：[1]河北省张家口市宣化区妇幼保健站,河北张家口075100 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《海南医学院学报》2017年第5期698-700,共3页Journal of Hainan Medical University

基　　金：河北省科学技术成果获奖项目(20120150)~~

摘　　要：目的:探讨血清炎性因子及胰岛素样生长因子(IGF)相关指标与妊娠期高血压疾病(HDP)的相关性。方法:选取2015年7月~2016年7月于我院分娩的HDP患者90例为研究对象,其中妊娠期高血压组43例,轻度子痫前期组28例,重度子痫前期组19例,另选取同期分娩的健康产妇40例为对照组。所有受试者于分娩前采集外周静脉血,采用免疫比浊法测定超敏-C反应蛋白(hs-CRP),放射免疫法测定肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6),ELISA法测定胰岛素生长因子-Ⅰ、-Ⅱ(IGF-Ⅰ、-Ⅱ)、胰岛素样生长因子结合蛋白(IGFBP-1)。结果:妊娠期高血压组、轻度子痫前期组、重度子痫前期组血清hs-CRP、TNF-α、IL-6水平高于对照组,且随病情的进一步加重而逐渐升高;妊娠期高血压组、轻度子痫前期组、重度子痫前期组血清IGF-Ⅰ、IGF-Ⅱ水平低于对照组,IGFBP-1水平高于对照组,且随着病情的进一步加重,IGF-Ⅰ、IGF-Ⅱ水平逐渐降低,IGFBP-1水平逐渐升高。结论:hs-CRP、TNF-α、IL-6及IGF-Ⅰ、IGF-Ⅱ、IGFBP-1与HDP的发生、发展密切相关。Objective： To explore the correlation of serum inflammatory cytokine and insulin-like growth factor （IGF） related indicators with hypertensive disorder complicating pregnancy （HDP）.Methods： A total of 90 patients with HDP who were admitted in our hospital from July, 2015 to July, 2016 for delivery were included in the study and divided into the pregnancy-induced hypertension group （n=43）, mild preeclampsia group （n=28）, and severe preeclampsia group （n=19）.Moreover, 40 healthy puerpera who were admitted in the same period for delivery were served as the control group.The peripheral venous blood before delivery was collected.The immunoturbidimetry was used to detect hs-CRP.The radioimmunoassay was used to detect TNF-α and IL-6.ELISA was used to detect IGF-I, IGF-Ⅱ, and IGFBP-1.Results： The serum hs-CRP, TNF-α, and IL-6 levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly higher than those in the control group （P〈0.05）, and were gradually elevated with the further aggravation of the disease （P〈0.05）.The serum IGF-I and IGF-Ⅱ levels in the pregnancy-induced hypertension group, mild preeclampsia group, and severe preeclampsia group were significantly lower than those in the control group （P〈0.05）, while IGFBP-1 level was significantly higher than that in the control group （P〈0.05）.With the further aggravation of the disease, IGF-I and IGF-II levels were gradually reduced （P〈0.05）, while IGFBP-1 level was gradually elevated （P〈0.05）.Conclusions： hs-CRP, TNF-α, IL-6, IGF-Ⅰ, IGF-Ⅱ, and IGFBP-1 are closely associated with the occurrence and development of HDP.

关 键 词：妊娠期高血压疾病 炎性因子 胰岛素样生长因子结合蛋白 胰岛素样生长因子 

分 类 号：R714.2[医药卫生—妇产科学]