良性前列腺增生症与心脑血管疾病危险因素关联性研究  

Association study between the risk factors of cardia-cerebrovascular disease and benign prostatic hyperplasi

作　　者：熊臣 王慧[2] 周游[1] 高兴成[1] 佘锡鸾[1] 

机构地区：[1]广州医科大学附属第三医院泌尿外科,广东广州510150 [2]蚌埠医学院研究生院,安徽蚌埠233000

出　　处：《广东医学》2017年第8期1180-1184,共5页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2013B022000097)

摘　　要：目的探讨心脑血管疾病危险因素高血压、糖尿病、肥胖、血脂异常与良性前列腺增生症(BPH)的关系。方法选取205例BPH患者的临床资料,然后分别按照是否合并高血压、糖尿病、肥胖、血脂异常分为BPH非高血压组(A1组,n=115)和BPH合并高血压组(A2组,n=90)、BPH非高血糖组(B1组,n=169)和BPH合并高血糖组(B2组,n=36)、BPH非肥胖组(C1组,n=142)和BPH合并肥胖组(C2组,n=63)、BPH非血脂异常组(D1组,n=151)和BPH合并血脂异常组(D2组,n=54),再分别进行两组间回顾性对比分析;最后进一步分析前列腺体积(PV)分别与收缩压(SBP)、舒张压(DBP)、空腹血糖(FBG)、糖化血红蛋白(HbA_(1C))、体质指数(BMI)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和血清前列腺特异性抗原(PSA)之间的相关性。结果 BPH分别合并高血压、糖尿病、肥胖患者与单纯性BPH患者相比,PV增大[(66.21±20.78)mL vs(56.79±29.31)mL、(68.98±27.67)mL vs(59.20±21.02)mL、(67.01±18.98)mL vs(58.45±23.64)mL],差异有统计学意义(P<0.05);并且高血压分级与PV呈正相关(rs=0.321,P<0.05);同样SBP、DBP、FBG、BMI、血清总PSA(t-PSA)和血清游离PSA(f-PSA)与PV呈正相关(r=0.229,P<0.05;r=0.188,P<0.05;r=0.180,P<0.05;r=0.311,P<0.05;r=0.161,P<0.05;r=0.161,P<0.05)。结论高血压、糖尿病、肥胖可能分别是促发BPH的危险因素,控制血压、血糖、体重可作为预防前列腺增生的手段之一。Objective To assess the correlations between the risk factors of cardia - cerebrovascular disease, in- cluding primary hypertension diabetes, obesity and blood lipids, and benign prostatic hyperplasia （BPH）. Methods A total of 205 cases of BPH were reviewed. These patients were divided according to whether complicating primary hypertension, diabetes, obesity or abnormal blood lipids respectively, the simple BPH group （A1, n = 115 ） and the BPH complicating primary hypertension （A2, n =90）; the simple BPH group （B1, n = 169） and the BPH complicating diabetes （B2, n = 36） ; the simple BPH group （C1, n = 142） and the BPH eomplicatittg obesity （C2, n =63） ; the simple BPH group （D1, n = 151 ） and the BPH complicating abnormal blood lipids （D2, n =54）. The clinical data were compared and the association between the risk factors and prostatic volume （PV） were analyzed. Results As compared without these risk factors groups, The PV in patients with risk factors, except for abnormal blood lipids, were significantly greater than those without them （66. 21 ±20. 78 mL vs. 56. 79 ±29. 31 mL, 68.98 ±27.67 mL vs. 59. 20 ±21.02 mL, 58.45 ±23.64 mL vs. 67.01 ±18.98 mL, respectively, P 〈0. 05）. And the PV was significantly positively correlated with hypertension, SBP, DBP, FBG, BMI, t-PSA and f-PSA （rs =0.321, P〈0.05; r =0.229, P〈0.05; r=0. 188, P〈 0.05; r=0.180, P〈0.05; r=0.311, P〈0.05; r=0.161, P〈0.05; r=0.161, P〈0.05）. Conclusion Primary hypertension, diabetes, and obesity may be important risk factors for BPH. BPH can be effectively prevented by means of improving primary hypertension, diabetes and obesity.

关 键 词：前列腺增生症 高血压 糖尿病 肥胖 血脂异常 

分 类 号：R697.32[医药卫生—泌尿科学]