白细胞介素-17及-35在子痫前期发病机制的研究进展  

Research progress of interleukin-17 and-35 in pre-eclampsia

作　　者：彭琦[1,2] 卢丹 

机构地区：[1]江苏省扬州大学临床医学院妇产科,225001 [2]江苏省扬州市江都人民医院妇产科,225200

出　　处：《中华妇幼临床医学杂志（电子版）》2017年第2期222-225,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：江苏省科技厅重点研究(社会发展)科技计划资助项目(BS2001018)~~

摘　　要：子痫前期(PE)是导致孕产妇和围生儿患病率和死亡率增高的主要原因之一。临床对于PE的发病机制迄今尚未阐明。近年研究结果显示,PE与母-胎免疫耐受失衡关系密切,发生PE时,机体白细胞介素(IL)-17表达上调,而IL-35表达下调,辅助性T细胞(Th)17与调节性T细胞(Treg)的免疫平衡(Th17/Treg)出现偏移。笔者拟就IL-17及-35的结构、生理功能及其在PE发病机制中作用的最新研究进展进行综述。Pre-eclampsia （PE） is one of important disorders that significantly contribute to the enhancement of maternal and neonatal mortality. The causes and mechanisms of PE are not fully clarified so far. In recent years, it has been shown by studies that PE is closely related to the imbalance of maternal-fetal immune tolerance. The expression of interleukin （IL）-17 is up-regulated, while the expression of IL-35 is down-regulated, and the immune balance of helper T cell （Th） 17 and regulatory T cell （Treg） is deviated in PE. The structures and functions of IL-17 and IL-35, and roles in the nosogenesis of PE are reviewed in this paper.

关 键 词：先兆子痫 白细胞介素-17 白细胞介素-35 T淋巴细胞 辅助诱导 T淋巴细胞 调节 免疫失衡 

分 类 号：R714.244[医药卫生—妇产科学]