人工肝联合内科治疗重型肝炎36例短期预后效果观察  

The clinical effect and short-term prognosticof the artificial liver support system combined with the medical therapy in the treatment of severe hepatitis

作　　者：林志鹏[1] 苏智军[1] 刘江福[1] 郭如意[1] 

机构地区：[1]福建医科大学附属泉州第一医院感染病科,福建362000

出　　处：《社区医学杂志》2017年第6期24-26,共3页Journal Of Community Medicine

基　　金：福建省泉州市技术研究与开发项目(Z[2014]0213)

摘　　要：目的探讨人工肝联合内科治疗重型肝炎例短期预后效果。方法选取2012年l2月—2015年l2月就诊的72例重型肝炎患者,随机分为研究组和对照组各36例,研究组接受人工肝联合内科综合治疗,对照组给予单纯内科综合治疗,观察两组入院时和治疗3个月后凝血酶原时间的国际标准化比率(international normalized ratio,INR)、总胆红素(totalbilirubin,TBIL)和血清肌酐(creatinine,Cr),计算终末期肝病模型(modelforend-stageliverdisease,MELD)分值,数据采用SPSS17.0进行统计学分析,P<0.05为差异有统计学意义。结果研究组治疗前后TBIL和INR比较差异均有统计学意义(t=2.014、4.576,P<0.05),且治疗后INR优于对照组,比较差异有统计学意义(t=3.235,P<0.05);治疗后研究组和对照组20≤MELD<30和30≤MELD<40的评分均低于治疗前(均P<0.05),且研究组优于对照组,比较差异均有统计学意义(t=2.278、2.860,均P<0.05)。结论人工肝联合内科治疗重型肝炎例短期预后效果良好,值得临床推广使用。Objective To investigate the clinical effect and short-term prognostic of the artificial liver support system combined with the medical therapy in the treatment of severe hepatitis. Methods 72 patients with severe hepatitis from December 2012 to December 2015 were randomly divided into the study groupand the control group,with each group 36 cases. The study group was given the artificial liver support system combined with the medical therapy, the control group was only given the traditional medical therapy. The internationalnormalized ratio（INR）, creatinine（Cr） and modelforend-stageliverdisease（MELD） was observed at admissionand first 3 months after admission. The data was statistically analyzed by SPSS 17.0, if P0.05, difference had statistical sense.Results There was significant difference in the comparison of TBIL and INR between before and after treatment of the study group（P0.05）, the INR in the study group was better thanthat in the control group after treatment, and there was significant difference between two groups（P0.05）. The MELD value in the study group and control group was 20 ≤ MELD30 and 30 ≤ MELD40, respectively, which were both lower than before treatment, the MELDvalue in the study group was better than that in the control group, and there was significant difference between two groups（P0.05）.Conclusion The clinical effect and short-term prognostic of the artificial liver support system combined with the medical therapy in the treatment of severe hepatitis was remarkable, and it was worthy of applicationin clinical work.

关 键 词：重型肝炎 人工肝 终末期肝病模型 短期预后 

分 类 号：R512.6[医药卫生—内科学]