减重支持训练治疗对早期心衰患者心功能、神经内分泌功能及血管内皮功能的影响  

Effect of partial body weight support training on the cardiac function,neuroendocrine function,and vascular endothelial function in patients with early heart failure

作　　者：那世敬[1] 李博[1] 魏晓冬[1] 李莹[1] 李大鹏[1] 

机构地区：[1]黑龙江省哈尔滨市第一医院,黑龙江哈尔滨150010

出　　处：《海南医学院学报》2017年第6期739-742,共4页Journal of Hainan Medical University

基　　金：大庆市卫生局科研课题(201303)~~

摘　　要：目的:探讨减重支持训练对早期心衰患者心脏康复过程中心功能、神经内分泌功能及血管内皮功能的影响。方法:选取98例早期心衰患者并随机分为观察组与对照组,对照组进行常规药物及康复治疗,观察组在对照组的基础上给予减重支持训练进行康复治疗,两组治疗周期均为3个月;检测康复训练前后两组心功能指标、神经内分泌激素水平及血管内皮功能指标的变化。结果:训练后两组LVESD、ESV均明显下降(P<0.05),观察组训练后LVESD、ESV均明显低于对照组(P<0.05);观察组训练后SV、CI、LVEF、FS较训练前显著升高(P<0.05),且观察组LVEF、FS显著高于对照组(P<0.05);对照组训练后LVEF显著升高(P<0.05);观察组训练后PRA、AngⅡ、ET、ALD水平均明显降低,NO明显升高(P<0.05),且上述指标改善明显优于对照组(P<0.05)。结论:减重支持训练可改善早期心衰患者心功能,抑制患者神经内分泌系统的过度激活,保护血管内皮功能,从而提高临床疗效。Objective：To explore the effect of partial body weight support training（PBWST）on the cardiac function,neuroendocrine function,and vascular endothelial function in patients with early heart failure.Methods：A total of 98 patients with early heart failure who were admitted in our hospital were included in the study and randomized into the observation group and the control group.The patients in the control group were given routine drugs and rehabilitation.On this basis,the patients in the observation group were given PBWST.The patients in both groups were treated for 3 months.The changes of cardiac function,neuroendocrine function,and vascular endothelial function indicators before and after rehabilitation in the two groups were detected.Results：LVESD and ESV after training in the two groups were significantly reduced（P〈0.05）.LVESD and ESV after training in the observation group were significantly lower than those in the control group（P 0.05）.SV,CI,LVEF,and FS after training in the observation group were significantly elevated when compared with that before treatment（P〈0.05）.LVEF and FS after training in the observation group were significantly higher than those in the control group（P〈0.05）.LVEF after treatment in the control group was significantly elevated（P〈0.05）.PRA,AngⅡ,ET,and ALD levels after treatment in the observation group were significantly reduced（P〈0.05）,while NO was significantly elevated（P〈0.05）,and the improvement of the above indicators was significantly superior to that in the control group（P〈0.05）.Conclusions：PBWST can improve the cardiac function in patients with early heart failure,inhibit the excessive activation of neuroendocrine system,and protect the vascular endothelial function in order to enhance the clinical efficacy.

关 键 词：早期心衰 减重支持训练 心脏康复 心功能 神经内分泌功能 血管内皮功能 

分 类 号：R541[医药卫生—心血管疾病]